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首页> 外文期刊>Expert opinion on therapeutic targets >Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy.
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Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy.

机译：探索肿瘤环境：以癌症相关的成纤维细胞为癌症治疗的靶标。

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Stroma cells contribute to the microenvironment that is essential for cancer growth, invasion and metastatic progression. Fibroblasts, often termed myofibroblasts or cancer-associated fibroblasts (CAFs), represent the most abundant cell type in the tumour stroma. The demonstrated tumour-promoting capacities of CAFs has increased the interest to exploit them as drug targets for anticancer therapy. Although single factors, such as platelet-derived growth factor, transforming growth factor-beta1, hepatocyte growth factor and matrix metalloproteinases have been identified as mediators in the fibroblast tumour interaction, the morphological and functional differences of CAFs compared with their normal counterparts are only incompletely understood. Recently, novel global methods for gene expression profiling were applied to comprehensively characterise CAFs from breast, pancreas, colon and basal cell cancer in their in situ environment. The analysis of different CAF preparations revealed regulated genes that were previously not described in the tumour-stroma context. Additionally, besides a few striking overlaps, the comparison of the gene lists indicates a high level of heterogeneity in the expression pattern of CAFs from different tumour types. Together, these studies emphasise the importance of cross-talk between stromal and malignant cells of the tumour. It is likely that the continued characterisation of this interaction, and the molecular identification of key mediators, will provide insights into tumour biology and suggest novel therapeutic options.
机译：基质细胞有助于形成微环境，而微环境对于癌症的生长，侵袭和转移进程至关重要。成纤维细胞通常称为肌成纤维细胞或癌症相关成纤维细胞（CAF），代表肿瘤基质中最丰富的细胞类型。证明的CAF具有促进肿瘤的能力，因此越来越有兴趣将其用作抗癌治疗的药物靶标。尽管已鉴定出血小板衍生生长因子，转化生长因子β1，肝细胞生长因子和基质金属蛋白酶等单一因素是成纤维细胞肿瘤相互作用的介体，但与正常人相比，CAF的形态和功能差异还不完全了解。近来，用于基因表达谱分析的新颖的全球方法被应用于在原位环境中全面鉴定来自乳腺癌，胰腺癌，结肠癌和基底细胞癌的CAF。对不同CAF制剂的分析揭示了以前在肿瘤基质环境中未描述的调控基因。另外，除了一些明显的重叠之外，基因列表的比较表明来自不同肿瘤类型的CAF的表达模式中的高度异质性。总之，这些研究强调了肿瘤的基质细胞和恶性细胞之间串扰的重要性。这种相互作用的持续表征以及关键介体的分子鉴定可能会提供对肿瘤生物学的见识，并提出新颖的治疗选择。

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