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首页> 外文期刊>Expert opinion on therapeutic targets >Therapeutic targets for antimetastatic therapy.
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Therapeutic targets for antimetastatic therapy.

机译：抗转移疗法的治疗目标。

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摘要

Metastases are responsible for most cancer deaths. Despite dramatic advances in cancer therapy, the presence of metastases implies a significantly shortened survival and reduced quality of remaining life. Aside from prevention of cancer altogether, or significant improvements in early detection for most cancers, effective novel therapeutic strategies targeting metastasis should provide the greatest clinical benefit. Metastasis research has shown that many of the initial steps in metastasis are completed with a high degree of efficiency and may have occurred by the time of clinical diagnosis. Therefore, targeting the later stages of metastasis may offer a more promising therapeutic approach for the development of antimetastatic therapies. Appropriate clinical strategies include targeting dormant solitary cells, active preangiogenic metastases, or vascularised metastases. Dormancy of solitary single cells, seen clinically and experimentally, may be an explanation for cancer recurrence. Eradication or inactivation of these dormant cells could provide large benefit for patients. However, little is known about what makes cancer cells dormant and, therefore, a greater knowledge of the mechanisms of dormancy is needed. This review discusses potential biological targets, as defined by the steps in the metastatic process, for antimetastatic therapies and provides examples of clinical strategies for preventing or treating successful metastasis.
机译：转移是导致大多数癌症死亡的原因。尽管癌症治疗取得了巨大进步，但转移灶的存在却显着缩短了生存期并降低了剩余生命质量。除了完全预防癌症或对大多数癌症的早期发现有显着改善外，靶向转移的有效新型治疗策略应可提供最大的临床益处。转移研究表明，转移的许多初始步骤均高效完成，并且可能在临床诊断时就已发生。因此，针对转移的后期阶段可能为抗转移疗法的发展提供更有希望的治疗方法。适当的临床策略包括靶向休眠的单核细胞，活跃的血管生成前转移灶或血管化转移灶。从临床和实验上看，孤单细胞的休眠可能是癌症复发的一种解释。这些休眠细胞的消除或失活可以为患者带来巨大的好处。但是，对于使癌细胞休眠的原因知之甚少，因此需要对休眠机制有更多的了解。这篇综述讨论了转移过程中所定义的潜在的生物学靶点，以用于抗转移疗法，并提供了预防或治疗成功转移的临床策略实例。

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