NF-kappaB in carcinoma therapy and prevention.

Brown M; Cohen J; Arun P; Chen Z; Van-Waes C

首页> 外文期刊>Expert opinion on therapeutic targets >NF-kappaB in carcinoma therapy and prevention.

【24h】

NF-kappaB in carcinoma therapy and prevention.

机译：NF-κB在癌症的治疗和预防中。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

BACKGROUND: NF-kappaB includes a family of signal-activated transcription factors that normally regulate responses to injury and infection but which are aberrantly activated in many carcinomas. OBJECTIVE: To review the activation and role of NF-kappaB in pathogenesis and as a target for treatment and prevention in carcinoma. METHODS: Evidence from experimental, epidemiological, preclinical studies and clinical trials cited in the literature are reviewed. RESULTS/CONCLUSION: Cumulative evidence implicates NF-kappaB in cell survival, inflammation, angiogenesis, spread and therapeutic resistance during tumor development, progression and metastasis of carcinomas. Non-specific natural and synthetic agents that inhibit NF-kappaB have demonstrated activity and safety in prevention or therapy. NF-kappaB-activating kinases and the proteasome are under investigation for targeted prevention and therapy of carcinoma.

机译：背景：NF-κB包括一类信号激活的转录因子，通常可调节对损伤和感染的反应，但在许多癌症中均被异常激活。目的：探讨NF-κB的激活及其在发病中的作用，并将其作为治疗和预防癌症的靶标。方法：综述了文献中引用的来自实验，流行病学，临床前研究和临床试验的证据。结果/结论：累积证据提示NF-kappaB在肿瘤发展，进展和转移过程中与细胞存活，炎症，血管生成，扩散和治疗抵抗有关。抑制NF-κB的非特异性天然和合成药物已证明在预防或治疗中具有活性和安全性。 NF-κB活化激酶和蛋白酶体正在研究中，用于靶向预防和治疗癌症。

著录项

来源
《Expert opinion on therapeutic targets》 |2008年第9期|共14页
作者
Brown M; Cohen J; Arun P; Chen Z; Van-Waes C;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Not free of; Prevention; Therapeutic procedure; Carcinoma; activate; 癌;

机译：并非没有;预防;治疗程序;癌;激活;癌;

相似文献

外文文献
中文文献
专利

1. NF-kappaB in carcinoma therapy and prevention. [J] . Brown M, Cohen J, Arun P, Expert opinion on therapeutic targets . 2008,第9期

机译：NF-κB在癌症的治疗和预防中。
2. NF-kappaB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapy. [J] . Sheng Hongmiao, Saxena Romil, Skill Nicholas James, Cancer letters . 2009,第2期

机译：NF-κB在人肝细胞癌中的抑制作用及其作为以索拉非尼为基础的治疗的辅助手段的潜力。
3. NF-kappaB as a molecular target in adjuvant therapy of gastrointestinal carcinomas. [J] . Yu YY, Li Q, Zhu ZG European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology . 2005,第4期

机译：NF-κB是胃肠道癌辅助治疗中的分子靶标。
4. Combined photodynamic therapy using Photofrin and radiotherapy versus radiotherapy alone in patients with inoperable obstructive nonsmall-cell bronchogenic carcinoma [C] . Stephen Lam, C.Grafton British Columbia Cancer Agency Vancouver BC Canada, P.Coy British Columbia Cancer Agency Vancounver BC Canada, International conference on photodynamic therapy and laser medicine . 1993

机译：使用Photofrin和放射疗法与放疗患者的合并光动力疗法在患有可操作性梗阻性的不适用的闭合性的非球细胞支气管癌患者中
5. Modulation of NF-kappaB and induction of endoplasmic reticulum stress potentiate chemotherapy-induced apoptosis in oral squamous cell carcinoma. [D] . Fribley, Andrew M. 2005

机译：口腔鳞状细胞癌中NF-κB的调节和内质网应激的诱导增强了化疗诱导的细胞凋亡。
6. Evaluation of Proinflammatory NF-kappaB Dependent Cytokines: IL-1α IL-6 IL-8 and TNF-α in Tissue Specimens and Saliva of Patients with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders [O] . Karolina Babiuch, Beata Kuśnierz-Cabala, Barbara Kęsek, 2020

机译：口腔鳞状细胞癌和口腔潜在恶性疾病患者组织标本和唾液中促炎性NF-κB依赖性细胞因子：IL-1αIL-6IL-8和TNF-α的评估
7. Inhibition of NF-kappaB enhances the cytotoxicity of virus-directed enzyme prodrug therapy and oncolytic adenovirus cancer gene therapy. [O] . Palmer, DH, Chen, MJ, Searle, PF, 2005

机译：抑制NF-κB增强了病毒导向的酶前药治疗和溶瘤腺病毒癌基因治疗的细胞毒性。
8. Constitutive Activation of NF-kappaB in Prostate Carcinoma Cells Through a Positive Feedback Loop: Implication of Inducible IKK-Related Kinase (IKKi) [R] . Budunova, I. V. 2006

机译：NF-κB在前列腺癌细胞中通过正反馈环的组成型激活：诱导型IKK相关激酶（IKKi）的意义

NF-kappaB in carcinoma therapy and prevention.

摘要

著录项

相似文献

相关主题

期刊订阅