Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma

Horn Dominik; Hess Jochen; Freier Kolja; Hoffmann Juergen; Freudlsperger Christian

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Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma

机译：靶向EGFR-PI3K-AKT-mTOR信号传导增强头颈部鳞状细胞癌的放射敏感性

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Introduction: Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by high resistance to radiotherapy, which critically depends on both altered signaling pathways within tumor cells and theirdynamic interaction with the tumor microenvironment.

机译：简介：头颈部鳞状细胞癌（HNSCC）通常以对放疗的高耐药性为特征，这主要取决于肿瘤细胞内信号通路的改变以及它们与肿瘤微环境的动态相互作用。

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《Expert opinion on therapeutic targets》 |2015年第6期|共11页
作者
Horn Dominik; Hess Jochen; Freier Kolja; Hoffmann Juergen; Freudlsperger Christian;
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正文语种 eng
中图分类药学;
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head and neck squamous cell carcinoma; mechanistic target of rapamycin; proteinkinase B; phosphoinositide 3-kinase; radiotherapy;

机译：头颈部鳞状细胞癌;雷帕霉素的作用靶点;蛋白激酶B;磷酸肌醇3-激酶;放射治疗;

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1. Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma [J] . Horn Dominik, Hess Jochen, Freier Kolja, Expert opinion on therapeutic targets . 2015,第6期

机译：靶向EGFR-PI3K-AKT-mTOR信号传导增强头颈部鳞状细胞癌的放射敏感性
2. Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma [J] . AdachiM., CuiC., DodgeC.T., Oral oncology . 2012,第12期

机译：靶向STAT3抑制头颈部鳞状细胞癌的生长并增强放射敏感性
3. Combined targeting of epidermal growth factor receptor, signal transducer and activator of transcription-3, and Bcl-X(L) enhances antitumor effects in squamous cell carcinoma of the head and neck. [J] . Boehm AL, Sen M, Seethala R, Molecular pharmacology. . 2008,第6期

机译：结合靶向表皮生长因子受体，转录3的信号转导子和激活剂以及Bcl-X（L）增强头颈部鳞状细胞癌的抗肿瘤作用。
4. Up-Regulation of Enhancer of Zeste Homolog 2 Is Associated Positively With Cyclin Dl Overexpression and Poor Clinical Outcome in Head and Neck Squamous Cell Carcinoma [C] . Wei Cao, Zhien Feng, Zhibin Cui, Academic Committee conference of Shanghai key lab of stomatology . 2011

机译：Zeste同源2的增强子的上调与Cyclin Dl过度表达和头颈部鳞状细胞癌的不良临床结果呈正相关。
5. PD-L1-specific helper T-cells exhibit effective antitumor responses: new strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma. [D] . 野﨑, 結 2019

机译：PD-L1特异性辅助性T细胞表现出有效的抗肿瘤反应：针对头颈部鳞状细胞癌中PD-L1的癌症免疫疗法的新策略。
6. EGFR-PI3K-AKT-mTOR Signaling in Head and Neck Squamous Cell Carcinomas - Attractive Targets for Molecular-Oriented Therapy [O] . Christian Freudlsperger, Jeffrey R. Burnett, Jay A. Friedman, -1

机译：EGFR-PI3K-AKT-MTOR在头部和颈部鳞状细胞癌中的信号传导 - 用于分子疗法的有吸引力的目标
7. Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons [O] . Eirini Terpsi Vitti, Andrzej Kacperek, Jason L. Parsons 2020

机译：靶向DNA双链断裂修复可增强HPV阳性和HPV阴性头部和颈鳞状细胞癌的放射敏感性，以光子和质子

Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma

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