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The effects of Rpd3 on fly metabolism, health, and longevity

机译：Rpd3对果蝇新陈代谢，健康和长寿的影响

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摘要

The epigenetic regulation of DNA structure and function is essential for changes in gene expression involved in development, growth, and maintenance of cellular function. Epigenetic changes include histone modifications such as methylation, acetylation, ubiquitination, and phosphorylation. Histone deacetylase (HDAC) proteins have a major role in epigenetic regulation of chromatin structure. HDACs are enzymes that catalyze the removal of acetyl groups from lysine residues within histones, as well as a range of other proteins including transcriptional factors. HDACs are highly conserved proteins divided into two families and based on sequence similarity in four classes. Here we will discuss the roles of Rpd3 in physiology and longevity with emphasis on its role in flies. Rpd3, the Drosophila HDAC1 homolog, is a class I lysine deacetylase and a member of a large family of HDAC proteins. Rpd3 has multiple functions including control of proliferation, development, metabolism, and aging. Pharmacological and dietary HDAC inhibitors have been used as therapeutics in psychiatry, cancer, and neurology. (C) 2016 Elsevier Inc. All rights reserved.
机译：DNA结构和功能的表观遗传学调控对于参与细胞功能发育，生长和维持的基因表达变化至关重要。表观遗传的变化包括组蛋白修饰，例如甲基化，乙酰化，泛素化和磷酸化。组蛋白脱乙酰基酶（HDAC）蛋白在染色质结构的表观遗传调控中起主要作用。 HDAC是催化从组蛋白内的赖氨酸残基以及一系列其他蛋白质（包括转录因子）上除去乙酰基的酶。 HDAC是高度保守的蛋白质，分为两个家族，并且基于四类的序列相似性。在这里，我们将讨论Rpd3在生理和长寿中的作用，重点是它在果蝇中的作用。果蝇HDAC1同源物Rpd3是I类赖氨酸脱乙酰基酶，是HDAC蛋白大家族的成员。 Rpd3具有多种功能，包括控制增殖，发育，代谢和衰老。药理和饮食HDAC抑制剂已在精神病学，癌症和神经病学中用作治疗剂。 （C）2016 Elsevier Inc.保留所有权利。

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