Targeting insulin sensitivity in the treatment of polycystic ovary syndrome.

Pasquali R; Gambineri A

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Targeting insulin sensitivity in the treatment of polycystic ovary syndrome.

机译：靶向胰岛素敏感性治疗多囊卵巢综合征。

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Targeting insulin resistance may result in a list of benefits for women with PCOS, including hormonal, metabolic and ovulatory (and fertility) improvements. The therapeutic strategy to treat PCOS should however depend on the clinical situation, the phenotype, the degree of androgen excess, age, the presence of infertility and the woman's desire to conceive, the presence of obesity and, finally, the spectrum of metabolic abnormalities and the need to treat or prevent long-term associated comorbidities. According to the needs, therapeutic options include, alone or in combination, lifestyle management, particularly in the presence of obesity, the use of insulin sensitizers, metformin and thiazolidinediones, antiandrogens or estro-progestins.

机译：靶向胰岛素抵抗可能会为患有PCOS的女性带来一系列好处，包括改善荷尔蒙，代谢和排卵（和生育力）。但是，治疗PCOS的治疗策略应取决于临床情况，表型，雄激素过多的程度，年龄，不孕症的存在和女性的受孕意愿，肥胖症的存在以及最终代谢异常和需要治疗或预防长期相关合并症。根据需要，治疗选择包括单独或组合进行生活方式管理，特别是在肥胖症的情况下，使用胰岛素敏化剂，二甲双胍和噻唑烷二酮，抗雄激素或雌孕激素。

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《Expert opinion on therapeutic targets》 |2009年第10期|共22页
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Pasquali R; Gambineri A;
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1. Targeting insulin sensitivity in the treatment of polycystic ovary syndrome. [J] . Pasquali R, Gambineri A Expert opinion on therapeutic targets . 2009,第10期

机译：靶向胰岛素敏感性治疗多囊卵巢综合征。
2. Insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome. [J] . Cheang KI, Baillargeon JP, Essah PA Metabolism: Clinical and Experimental . 2008,第10期

机译：多囊卵巢综合征女性的胰岛素刺激的含D-手性肌醇的肌醇磷酸聚糖介质释放与胰岛素敏感性相关。
3. Effect of dose escalation of metformin on clinical features, insulin sensitivity and androgen profile in polycystic ovary syndrome. [J] . Yasmin E, Glanville J, Barth J, European Journal of Obstetrics, Gynecology and Reproductive Biology: An International Journal . 2011,第1期

机译：二甲双胍剂量递增对多囊卵巢综合征临床特征，胰岛素敏感性和雄激素谱的影响。
4. Androgenic Suppression in Insulin Sensitive and Insulin Resistant Polycystic Ovary Syndrome Women. [C] . P. Vigil, W. Contreras, M. J. del Rio, International Congress of Andrology . 2009

机译：胰岛素敏感胰岛素抑制性多囊卵巢综合征女性的雄激抑制。
5. The genetics of insulin resistance in families with polycystic ovary syndrome. [D] . Matar, Jocelyne. 2006

机译：多囊卵巢综合征家庭胰岛素抵抗的遗传学。
6. Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. [O] . D A Ehrmann, J Sturis, M M Byrne, 1995

机译：多囊卵巢综合征的胰岛素分泌缺陷。非胰岛素依赖型糖尿病与胰岛素敏感性和家族史的关系。
7. Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus. [O] . Ehrmann, D A, Sturis, J, Byrne, M M, 1995

机译：多囊卵巢综合征的胰岛素分泌缺陷。非胰岛素依赖型糖尿病与胰岛素敏感性和家族史的关系。

Targeting insulin sensitivity in the treatment of polycystic ovary syndrome.

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