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Th22 and related cytokines in inflammatory and autoimmune diseases

机译：Th22和相关细胞因子在炎性和自身免疫性疾病中

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Introduction: Th22 and related cytokines regulate various processes and have been linked to diverse effects. The levels of Th22 and cytokine IL-22 are increased in several disorders and positively related to some autoimmune diseases. Preclinical studies have suggested that the inhibition or stimulation of IL-22 is an attractive approach to reverse the immune disorders. Simultaneously, considering many patients with refractory autoimmune diseases respond poorly to the therapies which are highly toxic, more effective therapies are to be examined. Areas covered: The role of Th22 cells and related cytokines and therapeutic strategies targeting them in many illnesses, especially inflammatory and autoimmune diseases. Expert opinion: Th22 cells and related cytokine IL-22 regulate multiple biological functions and play an important role in a number of inflammatory and autoimmune diseases. They have unique and attractive advantages for targeting. Targeting IL-22 has already been trialed in many mice experiments, showing better efficacy and fewer side effects compared with classical drugs. Targeting IL-22 or Th22 might provide pathogenetic treatment. However, Th22 subset is a recently identified Th subset and its associated research is extremely limited. Therefore, there are still many unanswered questions and further researches are warranted.
机译：简介：Th22和相关的细胞因子调节各种过程，并与多种作用有关。在一些疾病中，Th22和细胞因子IL-22的水平升高，并且与某些自身免疫性疾病呈正相关。临床前研究表明，抑制或刺激IL-22是逆转免疫疾病的一种有吸引力的方法。同时，考虑到许多难治性自身免疫性疾病患者对高毒性疗法的反应较差，因此需要研究更有效的疗法。涵盖的领域：Th22细胞和相关细胞因子的作用以及针对它们的治疗策略在许多疾病中，尤其是在炎症和自身免疫性疾病中。专家意见：Th22细胞和相关的细胞因子IL-22调节多种生物学功能，并在多种炎症和自身免疫性疾病中发挥重要作用。它们在定位方面具有独特而诱人的优势。靶向IL-22已在许多小鼠实验中进行了试验，与传统药物相比，具有更好的疗效和更少的副作用。靶向IL-22或Th22可能提供致病性治疗。但是，Th22子集是最近发现的Th子集，其相关研究极为有限。因此，仍然有许多悬而未决的问题，有待进一步研究。

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