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Endoglin for tumor imaging and targeted cancer therapy

机译：Endoglin用于肿瘤成像和靶向癌症治疗

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Introduction: Although cancer treatment has evolved substantially in the past decades, cancer-related mortality rates are still increasing. Therapies targeting tumor angiogenesis, crucial for the growth of solid tumors, mainly target vascular endothelial growth factor (VEGF) and have been clinically applied during the last decade. However, these therapies have not met high expectations, which were based on therapeutic efficacy in animal models. This can partly be explained by the upregulation of alternative angiogenic pathways. Therefore, additional therapies targeting other pro-angiogenic pathways are needed. Areas covered: The transforming growth factor (TGF)-β signaling pathway plays an important role in (tumor) angiogenesis. Therefore, components of this pathway are interesting candidates for anti-angiogenic therapy. Endoglin, a co-receptor for various TGF-β family members, is specifically overexpressed in tumor vessels and endoglin expression is associated with metastasis and patient survival. Therefore, endoglin might be a good candidate for anti-angiogenic therapy. In this review, we discuss the potential of using endoglin to target the tumor vasculature for imaging and therapeutic purposes. Expert opinion: Considering the promising results from various in vitro studies, in vivo animal models and the first clinical trial targeting endoglin, we are convinced that endoglin is a valuable tool for the diagnosis, visualization and ultimately treatment of solid cancers.
机译：简介：尽管在过去的几十年中，癌症治疗取得了长足的发展，但与癌症相关的死亡率仍在增加。针对实体血管生长至关重要的针对肿瘤血管生成的疗法主要针对血管内皮生长因子（VEGF），并且在最近十年中已在临床上应用。然而，这些疗法没有达到很高的期望，这是基于动物模型的治疗功效。这部分可以通过替代性血管生成途径的上调来解释。因此，需要靶向其他促血管生成途径的其他疗法。涵盖的领域：转化生长因子（TGF）-β信号通路在（肿瘤）血管生成中起着重要作用。因此，该途径的成分是抗血管生成治疗的有趣候选者。内皮糖蛋白是各种TGF-β家族成员的共同受体，在肿瘤血管中特异性过表达，内皮糖蛋白的表达与转移和患者生存有关。因此，内皮糖蛋白可能是抗血管生成治疗的良好候选者。在这篇综述中，我们讨论了使用内皮糖蛋白靶向肿瘤脉管系统进行成像和治疗的潜力。专家意见：考虑到各种体外研究，体内动物模型以及针对内皮糖蛋白的首项临床试验的有希望的结果，我们相信内皮糖蛋白是诊断，可视化和最终治疗实体癌的宝贵工具。

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