Osteoprotegerin expression during the micro- and macrometastatic phases of the osteoblastic metastasis in prostate cancer: Therapeutic implications

PneumaticosS.G.; ChristofidesA.; GkiokaE.; KalogeropoulosT.; MsaouelP.; KoutsilierisM.

首页> 外文期刊>Expert opinion on therapeutic targets >Osteoprotegerin expression during the micro- and macrometastatic phases of the osteoblastic metastasis in prostate cancer: Therapeutic implications

【24h】

Osteoprotegerin expression during the micro- and macrometastatic phases of the osteoblastic metastasis in prostate cancer: Therapeutic implications

机译：前列腺癌成骨细胞转移微观和宏观转移阶段的骨保护素表达：治疗意义

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Introduction: Osteoprotegerin (OPG) acts as a soluble decoy receptor for the bone marrow stroma cell-derived and osteoblast-derived receptor activator of nuclear factor-kB ligand (RANKL), thus regulating the RANK-mediated osteoclastogenesis and osteoclast-mediated bone resorption at the metastatic niche of cancer in skeleton. Areas covered: This article discusses the 'key' role of OPG expression during the early events of cancer cell invasion into the bone matrix and the subsequent events underlying the formation of osteoblastic metastasis, a unique event observed in human prostate cancer biology. Expert opinion: Understanding the cellular and molecular events implicated in bone metastasis can facilitate designing new therapeutic strategies for targeting early and/or late events in the metastasis processes. The RANKL/RANK/OPG pathway is a key regulator of pathological bone metabolism in metastatic sites. Targeted manipulation of these molecules may provide sustainable antitumor responses.

机译：简介：骨保护素（OPG）在骨髓基质细胞和成骨细胞衍生的核因子-kB配体（RANKL）受体激活剂中充当可溶性诱饵受体，从而调节RANK介导的破骨细胞生成和破骨细胞介导的骨吸收骨骼癌的转移性生态位。涵盖的领域：本文讨论了OPG表达在癌细胞浸入骨基质的早期事件以及随后成骨细胞转移形成的后续事件（在人类前列腺癌生物学中观察到的独特事件）期间的“关键”作用。专家意见：了解与骨转移有关的细胞和分子事件可以促进设计针对转移过程中早期和/或晚期事件的新治疗策略。 RANKL / RANK / OPG途径是转移部位病理性骨代谢的关键调节剂。这些分子的靶向操作可以提供可持续的抗肿瘤反应。

著录项

来源
《Expert opinion on therapeutic targets》 |2013年第12期|共9页
作者
PneumaticosS.G.; ChristofidesA.; GkiokaE.; KalogeropoulosT.; MsaouelP.; KoutsilierisM.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Bone microenvironment; OPG; Osteoblastic metastasis; Osteoclastogenesis; RANK; RANKL;

机译：骨微环境;OPG;成骨细胞转移;成骨细胞生成;RANK;RANKL;

相似文献

外文文献
中文文献
专利

1. Osteoprotegerin expression during the micro- and macrometastatic phases of the osteoblastic metastasis in prostate cancer: Therapeutic implications [J] . PneumaticosS.G., ChristofidesA., GkiokaE., Expert opinion on therapeutic targets . 2013,第12期

机译：前列腺癌成骨细胞转移微观和宏观转移阶段的骨保护素表达：治疗意义
2. Differential Expression of Matrix Metalloproteinase-2 Expression in Disseminated Tumor Cells and Micrometastasis in Bone Marrow of Patients with Nonmetastatic and Metastatic Prostate Cancer: Theoretical Considerations and Clinical Implications—An Immunocytochemical Study [J] . Nigel P.Murray, EduardoReyes, PabloTapia, Bone Marrow Research . 2012,第SUPPLEMENTa1期

机译：基质金属蛋白酶-2在非转移和转移性前列腺癌患者的扩散性肿瘤细胞和骨髓微转移中的差异表达：理论上的考虑和临床意义—免疫细胞化学研究
3. Dissecting the role of microRNAs in prostate cancer metastasis: implications for the design of novel therapeutic approaches [J] . Doldi Valentina, Pennati Marzia, Forte Barbara, Cellular and molecular life sciences: CMLS . 2016,第13期

机译：解剖microRNA在前列腺癌转移中的作用：对新型治疗方法设计的启示
4. Androgen Receptor Deregulation and the Transition to Castration Resistance in Prostate Cancer: Mechanisms and Potential Therapeutic Implications [C] . Karen E. Knudsen Genitourinary Cancers Symposium . 2011

机译：雄激素受体放松调节和前列腺癌抗阉割性的过渡：机制和潜在的治疗意义
5. Microarray analysis of gene expression in the rat prostate: Modulation by dietary fats and implications for prostate cancer [D] . Reyes Ramos, Niradiz de las Mercedes 2003

机译：大鼠前列腺中基因表达的微阵列分析：饮食脂肪的调控及其对前列腺癌的影响
6. Differential Expression of Matrix Metalloproteinase-2 Expression in Disseminated Tumor Cells and Micrometastasis in Bone Marrow of Patients with Nonmetastatic and Metastatic Prostate Cancer: Theoretical Considerations and Clinical Implications—An Immunocytochemical Study [O] . Nigel P. Murray, Eduardo Reyes, Pablo Tapia, 2012

机译：基质金属蛋白酶-2在非转移和转移性前列腺癌患者的扩散性肿瘤细胞和骨髓微转移中的差异表达：理论上的考虑和临床意义—免疫细胞化学研究
7. RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis [O] . Helen M. Sheldrake, Steven D. Shnyder, Andrew Gordon, 2012

机译：RGD结合整联蛋白在前列腺癌：表达模式和骨转移的治疗前景。

Osteoprotegerin expression during the micro- and macrometastatic phases of the osteoblastic metastasis in prostate cancer: Therapeutic implications

摘要

著录项

相似文献

相关主题

期刊订阅