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Targeting c-FLICE-like inhibitory protein (CFLAR) in cancer

机译：在癌症中靶向c-FLICE样抑制蛋白（CFLAR）

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Introduction: Evasion of apoptosis (programmed cell death) is one of the characteristic hallmarks of human cancers and may be caused by aberrant expression of antiapoptotic proteins. Among those is c-FLICE-like inhibitory protein (c-FLIP), a protein that not only blocks apoptosis signaling but also regulates additional cell death pathways. Areas covered: Because c-FLIP is regulated both at the transcriptional and posttranscriptional level by various mechanisms and is a short-lived protein with a rapid turnover, the regulation of c-FLIP expression represents a versatile tool to modulate cell death signaling pathways. Because c-FLIP is aberrantly expressed in various cancers, it represents a promising target for therapeutic intervention. Expert opinion: Therefore, insights into the molecular events that regulate c-FLIP expression and activity in human cancers will provide the basis for the development of new strategies to target c-FLIP expression in human cancers.
机译：简介：规避凋亡（程序性细胞死亡）是人类癌症的特征之一，可能是由于抗凋亡蛋白的异常表达引起的。其中包括c-FLICE样抑制蛋白（c-FLIP），该蛋白不仅可以阻断细胞凋亡信号传导，而且还可以调节其他细胞死亡途径。涵盖的领域：由于c-FLIP受多种机制在转录和转录后水平调控，并且是具有快速更新的短命蛋白质，因此c-FLIP表达的调控代表了一种调节细胞死亡信号传导途径的多功能工具。由于c-FLIP在各种癌症中异常表达，因此它代表了治疗干预的有希望的靶标。专家意见：因此，对调节人类癌症中c-FLIP表达和活性的分子事件的深入了解将为开发针对人类癌症中c-FLIP表达的新策略提供基础。

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