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Immediate early response gene X-1, a potential prognostic biomarker in cancers

机译：立即早期反应基因X-1，可能是癌症的预后生物标志物

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Introduction: The immediate early response gene X-1 (IEX-1) plays a pivotal role in the regulation of cell apoptosis, proliferation, differentiation and metabolism. Deregulation of IEX-1 expression has been confirmed in multiple cancers in humans, in association with either poor or better prognosis depending on the type and progression stages of the cancer. Areas covered: This review summarizes clinical studies of altered IEX-1 expression in ovarian, pancreatic, blood, breast and colorectal cancers, lymphoma and myeloma. The authors also outline the current understandings of the complex functions of IEX-1 gained from studies with animal models and tumor cell lines so as to help us comprehend the significance of the clinical findings. Expert opinion: IEX-1 holds great promise to be a valuable biomarker, either alone or in combination with other genes, for monitoring progression of some cancers. IEX-1 expression is highly sensitive to environmental cues and distinct between normal and cancer cells. However, use of IEX-1 as a biomarker remains a significant challenge because too little is understood about the mechanism underlying the diverse activities of IEX-1 and a standardized clinical assay for IEX-1 detection and validation of clinical results across different studies are still critically lacking.
机译：简介：立即早期反应基因X-1（IEX-1）在调节细胞凋亡，增殖，分化和代谢中起关键作用。已经证实，在人类的多种癌症中，IEX-1表达的失调与不良或更好的预后有关，这取决于癌症的类型和进展阶段。涵盖的领域：这篇综述总结了卵巢癌，胰腺癌，血液癌，乳腺癌和结直肠癌，淋巴瘤和骨髓瘤中IEX-1表达改变的临床研究。作者还概述了从动物模型和肿瘤细胞系研究中获得的对IEX-1复杂功能的当前理解，以帮助我们理解临床发现的重要性。专家意见：IEX-1有望成为一种有价值的生物标志物，无论是单独使用还是与其他基因组合使用，都可以监测某些癌症的进展。 IEX-1表达对环境线索高度敏感，在正常细胞和癌细胞之间是不同的。然而，使用IEX-1作为生物标志物仍然是一个严峻的挑战，因为对IEX-1多种活性的潜在机制了解甚少，而且跨不同研究的IEX-1检测和临床结果验证的标准化临床测定法仍然存在严重缺乏。

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