Therapeutic potential of manipulating suicidal erythrocyte death

Lang Florian; Jilani Kashif; Lang Elisabeth

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Therapeutic potential of manipulating suicidal erythrocyte death

机译：自杀性红细胞死亡的治疗潜力

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Introduction: Eryptosis, the suicidal erythrocyte death, is characterized by erythrocyte shrinkage and phosphatidylserine translocation to the erythrocyte surface. Eryptosis is triggered by cell stress such as energy depletion and oxidative stress, by Ca2+-entry, ceramide, caspases, calpain and/or altered activity of several kinases. Phosphatidylserine-exposing erythrocytes adhere to the vascular wall and may thus impede microcirculation. Eryptotic cells are further engulfed by phagocytes and thus rapidly cleared from circulation.

机译：简介：隐匿性自杀性红细胞死亡，其特征是红细胞收缩和磷脂酰丝氨酸转移至红细胞表面。细胞压力（例如能量耗竭和氧化应激），Ca2 +进入，神经酰胺，胱天蛋白酶，钙蛋白酶和/或几种激酶活性的改变触发了加密。暴露于磷脂酰丝氨酸的红细胞粘附在血管壁上，因此可能会阻碍微循环。吞噬细胞进一步吞噬了密码细胞，因此迅速从循环中清除。

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《Expert opinion on therapeutic targets》 |2015年第9期|共9页
作者
Lang Florian; Jilani Kashif; Lang Elisabeth;
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正文语种 eng
中图分类药学;
关键词
anemia; chronic kidney disease; diabetes; eryptosis; malaria; sickle cell disease; thrombosis;

机译：贫血;慢性肾脏疾病;糖尿病;隐匿性;疟疾;镰状细胞病;血栓形成;

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1. Therapeutic potential of manipulating suicidal erythrocyte death [J] . Lang Florian, Jilani Kashif, Lang Elisabeth Expert opinion on therapeutic targets . 2015,第9期

机译：自杀性红细胞死亡的治疗潜力
2. Storage of Erythrocytes Induces Suicidal Erythrocyte Death [J] . Elisabeth Lang, Vitaly I. Pozdeev, Haifeng C. Xu, Cellular Physiology and Biochemistry . 2016,第2期

机译：红细胞的储存诱导自杀性红细胞死亡
3. Stimulation of Suicidal Erythrocyte Death by Ceritinib-Treatment of Human Erythrocytes [J] . Abdulla Al Mamun Bhuyan, Elena Signoretto, Rosi Bissinger, Cellular Physiology and Biochemistry . 2016,第5期

机译：色瑞替尼治疗人红细胞对自杀性红细胞死亡的刺激
4. DNA Methylation Data to Predict Suicidal and Non-Suicidal Deaths: A Machine Learning Approach [C] . Rifat Zahan, Ian McQuillan, Nathaniel Osgood IEEE International Conference on Healthcare Informatics . 2018

机译：DNA甲基化数据预测自杀和非自杀死亡：一种机器学习方法
5. Dying before death to truly live: Therapeutic implications of the ego death experience for the treatment of death anxiety [D] . Sandler, Benjamin I. 2015

机译：在死亡之前死亡才能真正活着：自我死亡经历对死亡焦虑的治疗意义
6. Suicidal Erythrocyte Death in Metabolic Syndrome [O] . Ignazio Restivo, Alessandro Attanzio, Luisa Tesoriere, 2021

机译：代谢综合征的自杀红细胞死亡
7. Suicidal death of erythrocytes in cancer and its chemotherapy: A potential target in the treatment of tumor-associated anemia [O] . Elisabeth Lang, Rosi Bissinger, Syed M. Qadri, 2017

机译：癌症和化疗的红细胞的自杀性死亡：治疗肿瘤相关性贫血的潜在目标

Therapeutic potential of manipulating suicidal erythrocyte death

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