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首页> 外文期刊>Expert opinion on therapeutic targets >New uses for old copper-binding drugs: converting the pro-angiogenic copper to a specific cancer cell death inducer.
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New uses for old copper-binding drugs: converting the pro-angiogenic copper to a specific cancer cell death inducer.

机译：旧的铜结合药物的新用途：将促血管生成的铜转化为特定的癌细胞死亡诱导剂。

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BACKGROUND: The conventional approach toward anticancer drug development is a time-consuming and expensive procedure. OBJECTIVE/METHODS: One approach to expedite this process and achieve more affordable means is to discover new applications of existing drugs, since their pharmacokinetics and pharmacological profiles are well known. RESULTS: Our encouraging findings in recent studies reveal anticancer activities of several copper-binding ligands including disulfiram (an antialcoholism drug), clioquinol (used to treat Alzheimer's and Huntington's diseases) and diethyldithiocarbamate (an agent for HIV-1 infection treatment). CONCLUSION: These in vitro and in vivo studies have demonstrated that these archaic drugs can target and react with tumor cellular copper, forming complexes that act as potent proteasome inhibitors and apoptosis inducers.
机译：背景：抗癌药物开发的常规方法是耗时且昂贵的过程。目的/方法：加快这一过程并获得更实惠的方法的一种方法是发现现有药物的新应用，因为它们的药代动力学和药理学特性是众所周知的。结果：我们在最近的研究中令人鼓舞的发现揭示了一些铜结合配体的抗癌活性，包括双硫仑（一种抗酒精中毒药物），氯喹诺醇（用于治疗阿尔茨海默氏症和亨廷顿氏病）和二乙基二硫代氨基甲酸酯（一种治疗HIV-1的药物）。结论：这些体外和体内研究表明，这些古药可以靶向肿瘤细胞的铜并与之反应，形成可作为有效的蛋白酶体抑制剂和凋亡诱导剂的复合物。

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