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Alternaria is an Infrequent Cause of Keratitis: A Case Report and Review of the Literature

机译：交链孢菌是角膜炎的罕见病因：一例病例报告和文献复习

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Objective:To report a case of fungal keratitis caused by Alternaria in a 49-year-old female who developed an acute onset of eye infection after ocular trauma caused by an olive leaf.Methods:The clinical presentation, microbiological diagnosis, and therapeutic approaches are reported.Results:The patient was referred to our university hospital clinic with corneal abscess in her left eye. Before the start of an empirical antibacterial therapy (both topical and systemic), a swab of the cornea was obtained which at microscopic examination revealed a few fragments of hyphal elements, probably for the paucity of material collected. After one week, the corneal abscess had increased in size, and the corneal stroma was filled with filamentous structures similar to fungal hyphae. Oral and topical voriconazole was administered because of the clinical picture and the response of microbiological laboratory whose examination of the material removed from the anterior chamber showed numerous hyphal fragments identified by culture as Alternaria spp. The corneal abscess healed in two weeks, but the patient now has a corneal scar and is awaiting a corneal transplant.Conclusions:Ophthalmologists and microbiologists must take fungi into greater consideration as a possible cause of keratitis as they are emerging as the cause of this infectious disease in many countries. Voriconazole spreads well in the eye and is effective in the cure of fungal keratitis including those caused by Alternaria.
机译：目的：报道一名49岁女性因橄榄叶引起的眼外伤后急性发作眼感染的由链霉菌引起的真菌性角膜炎的病例。方法：临床表现，微生物学诊断和治疗方法结果：该患者因左眼角膜脓肿被转诊到我们大学医院诊所。在开始经验性抗菌治疗（局部和全身）之前，已获得了角膜拭子，该拭子在显微镜下检查发现了一些菌丝元素碎片，可能是因为所收集的材料很少。一周后，角膜脓肿增大，角膜基质充满类似于真菌菌丝的丝状结构。给予伏立康唑口服和局部用药是因为临床表现和微生物实验室的反应，微生物实验室对从前房取出的物质进行检查后发现许多菌丝碎片被培养物鉴定为链格孢菌。角膜脓肿在两周内he愈，但患者现在已经有角膜疤痕，正在等待角膜移植。许多国家都患有这种疾病。伏立康唑在眼内散布良好，可有效治疗真菌性角膜炎，包括由链霉菌引起的角膜炎。

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