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首页> 外文期刊>Eye >Perfluropropane (C3F8) gas injection followed by deep anterior lamellar keratoplasty (DALK) in severe keratoconus.
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Perfluropropane (C3F8) gas injection followed by deep anterior lamellar keratoplasty (DALK) in severe keratoconus.

机译：在严重的圆锥角膜上注入全氟丙烷（C3F8）气体，然后进行深前板层角膜移植术（DALK）。

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摘要

Uridine triphosphate (UTP)-glucose-1-phosphate uridylyltransferase (GalU; EC 2.7.7.9) is an enzyme that catalyzes the formation of uridine diphosphate (UDP)-glucose from UTP and glucose-1-phosphate. GalU is involved in virulence in a number of animal-pathogenic bacteria since its product, UDP-glucose, is indispensable for the biosynthesis of virulence factors such as lipopolysaccharide and exopolysaccharide. However, its function in Xanthomonas campestris pv. campestris, the phytopathogen that causes black rot in cruciferous plants, is unclear. Here, we characterized a galU mutant of X. campestris pv. campestris and showed that the X. campestris pv. campestris galU mutant resulted in a reduction in virulence on the host cabbage. We also demonstrated that galU is involved in bacterial attachment, cell motility, and polysaccharide synthesis. Furthermore, the galU mutant showed increased sensitivity to various stress conditions including copper sulfate, hydrogen peroxide, and sodium dodecyl sulfate. In addition, mutation of galU impairs the expression of the flagellin gene fliC as well as the attachment-related genes xadA, fhaC, and yapH. In conclusion, our results indicate involvement of galU in the virulence factor production and pathogenicity in X. campestris pv. campestris, and a role for galU in stress tolerance of this crucifer pathogen.
机译：尿苷三磷酸（UTP）-葡萄糖-1-磷酸尿嘧啶转移酶（GalU; EC 2.7.7.9）是一种催化UTP和葡萄糖-1-磷酸形成尿苷二磷酸（UDP）-葡萄糖的酶。 GalU在许多动物致病性细菌中均涉及毒力，因为其产品UDP-葡萄糖对于生物合成毒力因子（例如脂多糖和胞外多糖）是必不可少的。但是，它在Xanthomonas campestris pv中起作用。樟脑是导致十字花科植物黑腐病的植物病原体，目前尚不清楚。在这里，我们表征了X. campestris pv的galU突变体。 campestris并显示X. campestris pv。 campestris galU突变体导致寄主白菜的毒力降低。我们还证明了galU参与细菌附着，细胞运动和多糖合成。此外，galU突变体对包括硫酸铜，过氧化氢和十二烷基硫酸钠在内的各种胁迫条件显示出更高的敏感性。此外，galU的突变会损害鞭毛蛋白基因fliC以及与附着相关的基因xadA，fhaC和yapH的表达。总之，我们的结果表明galU参与了X. campestris pv的毒力因子生产和致病性。 ，以及galU在这种十字花科病原体的抗逆性中的作用。

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