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首页> 外文期刊>Gastrointestinal Endoscopy >Colonoscopic full-thickness resection of the colon in a porcine model as a prelude to endoscopic surgery of difficult colon polyps: a novel technique (with videos).
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Colonoscopic full-thickness resection of the colon in a porcine model as a prelude to endoscopic surgery of difficult colon polyps: a novel technique (with videos).

机译：猪模型中结肠的结肠镜全层切除术作为困难结肠息肉的内窥镜手术的前奏：一种新技术（带视频）。

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BACKGROUND: Colonoscopic full-thickness resection (CFTR) of the colon may obviate the need for surgical resection of benign lesions. OBJECTIVE: To develop an animal model for CFTR of the colon followed by endoscopic suture closure with through-the-endoscope devices. DESIGN: Pilot study. SETTING: University medical center. ANIMALS: Twenty pigs. INTERVENTIONS: A 2-cm circular area was resected on the antimesenteric side of the colon (phase 1, n = 10) and on the mesenteric side (phase 2, n = 10) by using an insulated tip knife cut followed by the use of a grasping forceps and a snare to resect and retrieve the specimen. The tissue apposition system was used to close the defect. MAIN OUTCOME MEASUREMENTS: Resection and closure times were recorded. The animals were euthanized at 2 weeks and examined for peritonitis, adhesions, wound healing, and T-tag injury to adjacent viscera. RESULTS: The CFTR was successful in all 20 attempts. The median resection time was 6 minutes (range 2.5-35 minutes). Suture closure was successful in 19 animals. It took a median time of 41 minutes (range 21-125 minutes) and 4 sutures to close the defect. Eighteen animals survived without clinical signs of distress; there was a well-healed scar without peritonitis or distant adhesions on necropsy at 2 weeks. One animal failed to thrive, and necropsy revealed mild peritonitis, small abscesses, distant adhesions, and a 2-mm hole at the suture site. Two of the 132 T-tags were inserted in the adjacent viscera. LIMITATIONS: Colon resection in the proximal colon was not studied. CONCLUSIONS: In this animal model, CFTR of the colon followed by suture closure can be accomplished successfully by using through-the-endoscope devices.
机译：背景：结肠结肠镜全层切除术（CFTR）可以消除对良性病变进行手术切除的需要。目的：建立结肠CFTR的动物模型，然后通过内窥镜装置内窥镜缝合缝合。设计：试点研究。地点：大学医学中心。动物：二十头猪。干预措施：用绝缘的尖刀切开结肠的肠系膜侧（1期，n = 10）和肠系膜侧（2期，n = 10）的2 cm圆形区域。一把抓钳和一个网罗以切除和取回标本。组织并置系统用于闭合缺损。主要观察指标：记录切除和闭合时间。在第2周对动物实施安乐死并检查其腹膜炎，粘连，伤口愈合和相邻内脏的T标签损伤。结果：CFTR在所有20次尝试中均成功。中位切除时间为6分钟（范围为2.5-35分钟）。缝线缝合成功的有19只动物。中位时间为41分钟（范围为21-125分钟），并用4根缝合线缝合以闭合缺损。 18只动物存活下来，没有临床困扰。 2周尸检时，伤口愈合良好，无腹膜炎或远处粘连。一只动物不能壮成长，尸检显示轻度腹膜炎，小脓肿，远处粘连和缝合部位的2毫米孔。 132个T标签中有两个插入了相邻的内脏。局限性：未研究近端结肠的结肠切除术。结论：在这种动物模型中，通过使用内窥镜设备可以成功地完成结肠的CFTR，然后缝合缝合。

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