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首页> 外文期刊>European Journal of Obstetrics, Gynecology and Reproductive Biology: An International Journal >First trimester assessment of Pentraxin-3 levels in women with primary unexplained recurrent pregnancy loss
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First trimester assessment of Pentraxin-3 levels in women with primary unexplained recurrent pregnancy loss

机译：对原发性原因不明的经常性流产的孕妇进行Pentraxin-3水平的早期妊娠评估

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Objective: To evaluate the potential role of measuring first-trimester maternal Pentraxin-3 levels in patients with primary unexplained recurrent pregnancy loss. Study design: A case control study was conducted in Ain Shams University Maternity Hospital. Cases included 45 women with primary unexplained recurrent pregnancy loss and early pregnancy failure admitted for medical or surgical termination of pregnancy. Controls (45 women) included a matched group of apparently healthy pregnant women who had at least one previous uneventful pregnancy with no previous obstetric history of adverse pregnancy outcomes. Maternal venous blood samples were collected for assay of Pentraxin-3 using enzyme-linked immunosorbent assay. The main outcome measure was the pregnancy outcome in women with elevated Pentraxin-3 levels. Results: 90 participants were statistically analyzed. In the patient group, the mean Pentraxin-3 level was 12.00 ± 4.07 ng/ml, while in the control group it was 1.69 ± 0.91 ng/ml. The difference was statistically significant (p < 0.001). In the patient group, Pentraxin-3 showed a significant positive correlation with the number of previous miscarriages (p = 0.038). Conclusion: Abnormally elevated Pentraxin-3 levels indicate the presence of an abnormally exaggerated intrauterine inflammatory or innate immune response that may cause pregnancy failure in women with primary unexplained recurrent pregnancy loss.
机译：目的：评估在未明原因的原发性反复妊娠流产患者中测量孕早期母体Pentraxin-3水平的潜在作用。研究设计：在Ain Shams大学妇产医院进行了一项病例对照研究。病例包括45名原发性原因不明的反复性妊娠丢失和早期妊娠失败的妇女，这些妇女因药物或手术终止妊娠而入院。对照组（45名妇女）包括一组看起来健康的孕妇，这些孕妇至少曾经有过一次平安无事的怀孕，而且以前没有产科不良妊娠结局的史。收集母体静脉血样品以使用酶联免疫吸附测定法测定Pentraxin-3。主要结果指标是Pentraxin-3水平升高的女性的妊娠结局。结果：90名参与者进行了统计分析。患者组中Pentraxin-3的平均水平为12.00±4.07 ng / ml，而对照组为1.69±0.91 ng / ml。差异具有统计学意义（p <0.001）。在患者组中，Pentraxin-3与先前的流产次数呈显着正相关（p = 0.038）。结论：Pentraxin-3水平异常升高表明存在原发性原因不明的反复性流产的孕妇异常夸大的子宫内炎症或先天免疫反应，可能导致妊娠失败。

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