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首页> 外文期刊>General hospital psychiatry >Quality of life in patients with Behcet's disease: the impact of major depression.
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Quality of life in patients with Behcet's disease: the impact of major depression.

机译：白塞病患者的生活质量：严重抑郁症的影响。

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OBJECTIVE: Behcet's disease (BD) is a multisystemic inflammatory disorder associated with high levels of depressive symptoms and lower quality of life (QoL). In this study, we aimed to investigate the impact of major depression (MD) on the QoL of patients with BD. METHOD: BD outpatients (n=25) and psychiatric outpatients (n=25) with only MD among the Axis I psychiatric disorders, and BD outpatients (n=25) and healthy controls (n=25) without any Axis I psychiatric disorder were included in the study. The Structured Clinical Interview for DSM-IV (SCID-I) was used to determine Axis I psychiatric disorders. Depression and QoL levels were assessed with the Beck Depression Inventory (BDI) and the World Health Organization QoL Assessment-Brief (WHOQOL-BREF), respectively. RESULTS: There was no significant difference with regard to demographic characteristics between the groups. Psychiatric and BD patients with MD had significantly lower overall WHOQOL-BREF subscale scores than BD patients without MD and healthy controls. No significant difference was found in terms of QoL between the groups of psychiatric and BD patients with MD, nor between the groups of BD patients without MD and healthy controls. Overall, there was a significantly negative correlation between all WHOQOL-BREF subscale and BDI scores in BD patients. CONCLUSION: The study suggests that concurrent MD has a negative impact on QoL of BD patients and that QoL is negatively correlated with the severity of depressive symptoms.
机译：目的：白塞病（BD）是一种多系统性炎症性疾病，与高水平的抑郁症状和较低的生活质量（QoL）相关。在这项研究中，我们旨在研究重度抑郁（MD）对BD患者QoL的影响。方法：在第I轴精神病患者中仅MD的BD门诊患者（n = 25）和精神科门诊患者（n = 25），无第I轴精神病患者的BD门诊患者（n = 25）和健康对照（n = 25）为包括在研究中。 DSM-IV（SCID-1）的结构化临床访谈被用来确定Axis I精神病。抑郁和生活质量水平分别通过贝克抑郁量表（BDI）和世界卫生组织生活质量评估摘要（WHOQOL-BREF）进行评估。结果：两组之间的人口统计学特征无显着差异。与没有MD和健康对照的BD患者相比，患有MD的精神病患者和BD患者的WHOQOL-BREF总分量表得分明显较低。精神病患者和BD患者的MD组之间，以及没有MD患者的BD患者组和健康对照组之间在QoL方面均无显着差异。总体而言，BD患者中所有WHOQOL-BREF分量表与BDI评分之间均存在显着负相关。结论：该研究提示并发MD对BD患者的QoL有负面影响，并且QoL与抑郁症状的严重程度负相关。

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