• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>General hospital psychiatry >Long-term topiramate treatment of psychotropic drug-induced weight gain: a retrospective chart review.
【24h】

Long-term topiramate treatment of psychotropic drug-induced weight gain: a retrospective chart review.

机译：长期托吡酯治疗精神药物引起的体重增加：回顾性图表回顾。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: The objective of this study was to determine the efficacy and tolerability of long-term topiramate treatment of psychotropic drug-induced weight gain. METHOD: We conducted a retrospective review of the charts of patients treated with add-on topiramate in order to control weight gain induced by psychotropic drugs (antipsychotic drugs, lithium or valproate). RESULTS: The case series consisted of 100 patients. The mean final dose of topiramate was 186.8+/-138.3 mg/day, whereas the median dose was 200 mg/day for a total treatment duration of 41+/-38 weeks. Adverse events led to topiramate discontinuation in 22% of the sample. A significant reduction in body mass index was observed between the first and last measures, from 29.7+/-3.6 to 28+/-3.3 (t=5.82, P<.0005). The reduction in body mass index was greater in patients treated with antipsychotic drugs than in those treated with lithium or valproate alone. No difference was found between subjects with and those without comorbid active substance abuse or dependence. CONCLUSIONS: In this retrospective case series, topiramate was found to be effective in reversing weight gain associated with antipsychotic drugs, lithium or valproate. Tolerability of topiramate was an issue in some patients.
机译：目的：本研究的目的是确定长期托吡酯治疗精神药物引起的体重增加的疗效和耐受性。方法：我们回顾性研究了接受托吡酯治疗的患者图表，以控制精神药物（抗精神病药，锂或丙戊酸盐）引起的体重增加。结果：该病例系列由100例患者组成。托吡酯的平均最终剂量为186.8 +/- 138.3 mg /天，而中位剂量为200 mg /天，总治疗时间为41 +/- 38周。不良事件导致22％的样品停用托吡酯。在第一个测量和最后一个测量之间，体重指数显着下降，从29.7 +/- 3.6降至28 +/- 3.3（t = 5.82，P <.0005）。用抗精神病药物治疗的患者的体重指数下降大于仅使用锂或丙戊酸盐治疗的患者。在患有和没有合并活性物质滥用或依赖性的受试者之间没有发现差异。结论：在该回顾性病例系列中，发现托吡酯可有效逆转与抗精神病药，锂或丙戊酸盐有关的体重增加。托吡酯的耐受性在某些患者中是一个问题。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号