Carriers for the delivery of a vaccine against respiratory syncytial virus.

Cranage M; Taylor G

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Carriers for the delivery of a vaccine against respiratory syncytial virus.

机译：运送抗呼吸道合胞病毒疫苗的载体。

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Respiratory syncytial virus (RSV) is a major cause of bronchiolitis and pneumonia in young children and the elderly. Despite its clinical importance, there is no licensed vaccine available at present. Vaccine development has been hampered by observations of increased pathology after RSV infection in infants vaccinated with formalin-inactivated RSV; incomplete immunity following natural infection; and the need to be effective during the neonatal period when levels of maternal antibody are high. Four categories of RSV vaccine carriers--live-attenuated RSVs, recombinant vectors expressing the protective antigens of RSV, DNA vaccines and subunit vaccines--have been evaluated in animal models and/or clinical trials. So far, studies with live-attenuated virus vaccines highlight the need to improve immunogenicity whilst maintaining a suitable level of attenuation. Studies with recombinant vectors, DNA and subunit vaccines illustrate the pivotal nature of the vaccine carrier in determining the balance between immune-mediated protection against infection and the induction of immune-mediated pulmonary pathology.

机译：呼吸道合胞病毒（RSV）是导致幼儿和老年人支气管炎和肺炎的主要原因。尽管具有临床重要性，但目前尚无许可的疫苗。观察到用福尔马林灭活的RSV疫苗接种的婴儿在RSV感染后病理增加，从而阻碍了疫苗的发展。自然感染后免疫力不完全;并且在母体抗体水平高的新生儿期需要有效。已在动物模型和/或临床试验中评估了四类RSV疫苗载体-减毒活RSV，表达RSV保护性抗原的重组载体，DNA疫苗和亚单位疫苗。迄今为止，减毒活疫苗的研究强调需要在保持适当的减毒水平的同时提高免疫原性。重组载体，DNA和亚单位疫苗的研究表明，疫苗载体在确定免疫介导的抗感染保护与诱导免疫介导的肺部病理之间的平衡方面具有关键性。

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《Expert opinion on biological therapy》 |2005年第7期|共14页
作者
Cranage M; Taylor G;
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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
Vaccines; Rous sarcoma virus; Respiratory syncytial virus; Pathology processes; 疫苗;

机译：疫苗;卢氏肉瘤病毒;呼吸道合胞病毒;病理过程;疫苗;

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专利

1. Carriers for the delivery of a vaccine against respiratory syncytial virus. [J] . Cranage M, Taylor G Expert opinion on biological therapy . 2005,第7期

机译：运送抗呼吸道合胞病毒疫苗的载体。
2. Mucosal gene expression vaccine: a novel vaccine strategy for respiratory syncytial virus. [J] . Mohapatra SS The Pediatric infectious disease journal . 2003,第2Suppla期

机译：粘膜基因表达疫苗：呼吸道合胞病毒的新型疫苗策略。
3. Induction of protective effector immunity to prevent pathogenesis caused by the respiratory syncytial virus. Implications on therapy and vaccine design [J] . EspinozaJ.A., BuenoS.M., RiedelC.A., Immunology: An Official Journal of the British Society for Immunology . 2014,第1期

机译：诱导保护性效应器免疫，以预防由呼吸道合胞病毒引起的发病。对治疗和疫苗设计的影响
4. A meta-analysis of vaccine effectiveness against bovine herpesvirus, bovine viral diarrhea virus, bovine respiratory syncytial virus, and parainfluenza-type 3 virus in cattle for bovine respiratory di [C] . M.E. Theurer, R.L. Larson, B.J. White Annual Conference of the American^Association^of^Bovine^Practitioners., Conference . 2014

机译：对牛疱疹病毒，牛病毒性腹泻病毒，牛呼吸道和血酸病毒和牛牛呼吸道牛牛牛呼吸道型病毒和Parainfluenza型3病毒的疫苗效果的荟萃分析
5. Characterization of vaccine-associated enhanced respiratory disease (VAERD) in swine administered an inactivated delta-cluster influenza vaccine and challenged with pandemic A/H1N1 virus. [D] . Gauger, Phillip C. 2012

机译：接种灭活的δ-集群流感疫苗并受到大流行A / H1N1病毒攻击的猪中与疫苗相关的增强呼吸道疾病（VAERD）的特征。
6. Induction of protective effector immunity to prevent pathogenesis caused by the respiratory syncytial virus. Implications on therapy and vaccine design [O] . Janyra A Espinoza, Susan M Bueno, Claudia A Riedel, 2014

机译：诱导保护性效应物免疫以预防由呼吸道合胞病毒引起的发病机理。对治疗和疫苗设计的影响
7. Faculty Opinions recommendation of Induction of potent neutralizing antibody responses by a designed protein nanoparticle vaccine for respiratory syncytial virus. [O] . Rino Rappuoli 2019

机译：教师观点推荐诱导有效的中和抗体反应对呼吸合胞病毒的设计蛋白纳米颗粒疫苗的建议。
8. Laboratory and Antigenic Studies of Respiratory Syncytial Virus;Evaluation of Respiratory Syncytial, Meningococcal,and Pneumococcal Polysaccharide Vaccines. [R] . forsyth,ben r. phillips,charles a. 1971

机译：呼吸道合胞病毒的实验室和抗原研究;呼吸道合胞体，脑膜炎球菌和肺炎球菌多糖疫苗的评估。

Carriers for the delivery of a vaccine against respiratory syncytial virus.

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