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The potential of cell-based therapy in lung diseases

机译：基于细胞的疗法在肺部疾病中的潜力

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Introduction: Many lung diseases have high morbidity and mortality rates and there are no cures or treatments apart from mechanical ventilation or transplantation. Cell-based therapies are currently an area of intense research, and many groups are working to translate successful in vitro results into treatments that are safe for patients. Areas covered: This review discusses several types of stem and progenitor cells that have been proven likely candidates for cell therapies, as well as their applications so far in specific acute and chronic lung diseases, focusing on their mechanisms of action and how best they can be directed toward clinical aims. Expert opinion: The research on cell therapies for the lung, particularly regarding mesenchymal stem cells (MSCs), is promising, but there is still much uncertainty surrounding the mechanisms of MSC action and the factors relevant to clinical applications such as the optimal timing of dosage. Future studies will focus on the microenvironment of the stem cells, including the role of microRNAs and extracellular vesicles.
机译：简介：许多肺部疾病的发病率和死亡率很高，除了机械通气或移植外，没有其他治愈或治疗方法。基于细胞的疗法目前是一个研究热点，许多小组正在努力将成功的体外结果转化为对患者安全的疗法。涵盖的领域：本文讨论了几种已被证明可能用于细胞治疗的干细胞和祖细胞，以及它们迄今为止在特定的急性和慢性肺部疾病中的应用，着眼于它们的作用机理以及它们的最佳状态。针对临床目标。专家意见：肺细胞疗法，特别是间充质干细胞（MSCs）的研究是有前途的，但是围绕MSC作用机理以及与临床应用相关的因素（例如最佳给药时间）仍然存在很多不确定性。未来的研究将集中在干细胞的微环境上，包括微RNA和细胞外囊泡的作用。

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