• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Expert opinion on biological therapy >Zostavax: A subcutaneous vaccine for the prevention of herpes zoster
【24h】

Zostavax: A subcutaneous vaccine for the prevention of herpes zoster

机译：Zostavax：一种预防带状疱疹的皮下疫苗

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Herpes zoster (HZ) occurs as a reactivation of dormant varicella zoster virus (VZV), and occurs more frequently in the aging population or the immunocompromised due to waning cell-mediated immunity. Up to 1 million cases of HZ are reported annually in the USA with an estimated 10-30% of the population being affected by shingles in their lifetime. HZ is a debilitating illness, and while mortality is low, morbidity remains a significant cause for concern with prevention efforts aimed at reducing VZV reactivation and its complications. The HZ vaccine was approved by the US Food and Drug Administration for individuals aged 50-years or older. However, the Center for Disease Control and Prevention's Advisory Committee for Immunization Practices recommends the vaccine in individuals aged 60-years or older. Areas covered: Recent literature investigating the efficacy and indications of live attenuated zoster vaccine. Expert opinion: Live attenuated zoster vaccine is safe and efficacious in preventing HZ and decreasing the morbidity associated with postherpetic neuralgia. The vaccine is FDA approved in individuals aged 50-years or older but further studies are warranted to investigate the vaccine's efficacy in immunosuppressed and immunocompromised patients.
机译：简介：带状疱疹（HZ）是作为休眠性水痘带状疱疹病毒（VZV）的再激活而发生的，并且在衰老人群中或由于细胞介导的免疫力减弱而免疫受损时更常发生。在美国，每年报告多达100万例HZ病例，估计一生中有10-30％的人口受到带状疱疹的影响。 HZ是一种使人衰弱的疾病，尽管死亡率低，但发病率仍然是引起人们关注的重要原因，旨在减少VZV的再激活及其并发症。 HZ疫苗已获得美国食品和药物管理局的批准，适用于50岁以上的人群。但是，疾病预防控制中心免疫实践咨询委员会建议在60岁以上的人群中使用该疫苗。涵盖领域：研究减毒带状疱疹活疫苗的功效和适应症的最新文献。专家意见：带减毒的带状疱疹疫苗在预防HZ和减少带状疱疹后神经痛相关的发病率方面是安全有效的。该疫苗已获得FDA批准，年龄在50岁或50岁以上，但是有必要进行进一步的研究，以研究该疫苗在免疫抑制和免疫功能低下患者中的功效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号