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Stem-cell therapy for erectile dysfunction

机译：干细胞治疗勃起功能障碍

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Introduction: Stem cells (SCs) have been investigated for the treatment of erectile dysfunction (ED). Areas covered: This review covers key disease targets and all 33 preclinical studies, including their use of SC types, animal models, transplantation routes, and outcome assessment methods. Expert opinion: In the past one and half years there have been more stem-cell-for-erectile-dysfunction studies than the prior 8 years combined. These new studies tend to use combinatory treatment approaches by modifying or supplementing SCs with angiogenic or neurotrophic genes or proteins. However, when considering all risks and benefits, these combinatory approaches do not seem more advantageous than single-SC approaches. Another trend is the choice of transplantation routes other than the standard intracavernous (IC) injection. However, with the exception of intravenous injection, these new transplantation approaches are more cumbersome than IC injection and yet offer no evidence of producing better outcomes. In contrast to these variations, a consensus among these studies is the suggestion that paracrine action, as opposed to cellular differentiation, is the principal therapeutic mechanism. In conclusion, IC injection of a single SC type should be the choice protocol for initial clinical trials, and this is clearly the case with two clinical trials that are currently recruiting patients.
机译：简介：已经对干细胞（SCs）治疗勃起功能障碍（ED）进行了研究。涵盖领域：这篇综述涵盖了主要疾病靶标和所有33项临床前研究，包括其对SC类型的使用，动物模型，移植途径和结果评估方法。专家意见：在过去的一年半中，干细胞对勃起功能障碍的研究比前8年的总和还多。这些新的研究倾向于使用组合治疗方法，通过用血管生成或神经营养性基因或蛋白质修饰或补充SC来使用。但是，在考虑所有风险和收益时，这些组合方法似乎没有比单SC方法更具优势。另一个趋势是选择标准海绵体（IC）注射以外的移植途径。但是，除了静脉注射外，这些新的移植方法比IC注射更麻烦，但没有提供产生更好结果的证据。与这些变化相反，这些研究之间的共识是，与细胞分化相反，旁分泌作用是主要的治疗机制。总之，单一SC类型的IC注射应该是初始临床试验的选择方案，而目前正在招募患者的两项临床试验显然就是这种情况。

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