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首页> 外文期刊>Expert opinion on biological therapy >Surfactant protein D/anti-Fc receptor bifunctional proteins as a tool to enhance host defence.
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Surfactant protein D/anti-Fc receptor bifunctional proteins as a tool to enhance host defence.

机译：表面活性剂蛋白D /抗Fc受体双功能蛋白可增强宿主防御能力。

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摘要

BACKGROUND: Drug-resistant pathogens are an increasing threat, particularly for hospitalised patients. In search of a new approach in pathogen targeting, we developed bifunctional proteins that combine broad spectrum pathogen recognition with efficient targeting to phagocytes. Pathogen recognition is provided by a recombinant fragment of surfactant protein D (rfSP-D) while targeting to phagocytic cells is accomplished by coupling rfSP-D to F(ab') fragments directed against Fcalpha receptor I (FcalphaRI) or Fcgamma receptor I (FcgammaRI). FcalphaRI and FcgammaRI are expressed on myeloid cells, and induce rapid internalisation of particles after crosslinking. OBJECTIVE/METHODS: In this review we discuss the roles of SP-D and Fc receptors in host defence as a rationale for rfSP-D/anti-FcR bifunctional proteins. Furthermore we summarise the available data on rfSP-D/anti-FcR proteins as well as opportunities and considerations for future use of such bifunctional proteins. RESULTS/CONCLUSION: rfSP-D/anti-FcRbifunctional proteins could be of great value for the treatment of a variety of infectious diseases. The focus in the near future should be on proof-of-principle by testing the bifunctional proteins in different mouse models of infectious disease.
机译：背景：耐药性病原体正日益增加的威胁，特别是对于住院患者而言。为了寻找病原体靶向的新方法，我们开发了将广谱病原体识别与有效靶向吞噬细胞相结合的双功能蛋白。病原体识别是由表面活性剂蛋白D（rfSP-D）的重组片段提供的，而靶向吞噬细胞的方法是将rfSP-D与针对Fcalpha受体I（FcalphaRI）或Fcgamma受体I（FcgammaRI的F（ab'）片段偶联来实现）。 FcalphaRI和FcgammaRI在髓样细胞上表达，并在交联后引起颗粒的快速内在化。目的/方法：在本综述中，我们讨论SP-D和Fc受体在宿主防御中的作用，作为rfSP-D / anti-FcR双功能蛋白的基本原理。此外，我们总结了有关rfSP-D / anti-FcR蛋白的可用数据，以及此类双功能蛋白未来使用的机会和考虑因素。结果/结论：rfSP-D /抗FcR双功能蛋白对于治疗多种传染病具有重要价值。在不久的将来，重点应放在通过不同传染病小鼠模型中的双功能蛋白测试来证明原理。

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