Anti-sense oligonucleotide therapies for the treatment of hyperlipidaemia

Wierzbicki Anthony S.; Viljoen Adie

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Anti-sense oligonucleotide therapies for the treatment of hyperlipidaemia

机译：用于治疗高脂血症的反义寡核苷酸疗法

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Introduction: Anti-sense oligonucleotide (ASO) therapies are a new development in clinical pharmacology offering greater specificity compared to small molecule inhibitors and the ability to target intracellular process' not susceptible to antibody-based therapies.

机译：简介：反义寡核苷酸（ASO）疗法是临床药理学的一项新进展，与小分子抑制剂相比具有更高的特异性，并且具有靶向细胞内过程的能力，这种能力对基于抗体的疗法不敏感。

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《Expert opinion on biological therapy》 |2016年第9期|共10页
作者
Wierzbicki Anthony S.; Viljoen Adie;
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正文语种 eng
中图分类治疗学;
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Familial hypercholesterolaemia; lipoprotein(a); lipoprotein lipase deficiency; familial chylomcronaemia syndrome; lipodystrophy; angiopoietin-like protein 3 (ANGPTL3); antisense oligonucleotide; treatment;

机译：家族性高胆固醇血症;脂蛋白（a）;脂蛋白脂肪酶缺乏症;家族性乳糜泻综合征;脂肪营养不良;血管生成素样蛋白3（ANGPTL3）;反义寡核苷酸;治疗;

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1. Anti-sense oligonucleotide therapies for the treatment of hyperlipidaemia [J] . Wierzbicki Anthony S., Viljoen Adie Expert opinion on biological therapy . 2016,第9期

机译：用于治疗高脂血症的反义寡核苷酸疗法
2. Modifying Renal Gene Expression by Anti-Sense Oligonucleotide Delivery during Normothermic Machine Perfusion [J] . Sewpaul Avinash, Figueiredo Rodrigo S., Bates Lucy, Transplantation: Official Journal of the Transplantation Society . 2018,第9Suppla期

机译：通过在常温机灌注期间通过反义寡核苷酸输送来改变肾基因表达
3. Phosphorothioate anti-sense oligonucleotides: the kinetics and mechanism of the generation of the sulfurising agent from phenylacetyl disulfide (PADS) [J] . James L. Scotson, Benjamin I. Andrews, Andrew P. Laws, Organic & biomolecular chemistry . 2016,第35期

机译：硫代磷酸酯反义寡核苷酸：由苯基乙酰基二硫化物（PADS）生成硫化剂的动力学和机理
4. Layer-by-layer Polyelectrolyte Cell Encapsulation And Its Potential Use In Anti-sense Oligonucleotide Delivery [C] . A.L. Hillberg, M. Tabrizian Society for Biomaterials Transactions of the 30th Annual Meeting amp; Exposition vol.28: New Applications and Technologies; 20050427-30; Memphis,TN(US) . 2005

机译：层状聚电解质细胞包封及其在反义寡核苷酸传递中的潜在应用
5. The efficacy of three treatments for depression: Morita psychotherapy, dietary brain -chemistry treatment, and the combination of Morita psychotherapy/brain-chemistry treatment as compared to no-treatment control. [D] . Hanson, Lynn M. 2002

机译：三种治疗抑郁症的功效：森田心理疗法，饮食性脑化学疗法以及森田心理疗法/脑化学疗法相结合的治疗（与未治疗对照相比）。
6. Beneficial Metabolic Effects of CB1R Anti-Sense Oligonucleotide Treatment in Diet-Induced Obese AKR/J Mice [O] . Yuting Tang, George Ho, Yaxin Li, -1

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7. B1-02: A Phase 1-2 study of the anti-sense oligonucleotide OGX-011 in combination with a platinum/gemcitabine regimen as first-line therapy for advanced non-small cell lung cancer [O] . Laskin Janessa, Hao Desiree, Canil Christina, 2007

机译：B1-02：反义寡核苷酸OGX-011与铂/吉西他滨方案联合作为晚期非小细胞肺癌的一线治疗的1-2期研究

Anti-sense oligonucleotide therapies for the treatment of hyperlipidaemia

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