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Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins.

机译：双连续立方液晶作为肽和蛋白质的持续输送系统。

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IMPORTANCE OF THE FIELD: Self-assembling lipid-based liquid crystalline systems are a broad and active area of research. Of these mesophases, the cubic phase with its highly twisted bilayer and two non-intersecting water channels has been investigated extensively for drug delivery. The cubic phase has been shown to accommodate and control the release of drugs with varying physicochemical properties. Also, the lipids used to prepare these delivery systems are generally cheap, safe and biodegradable, making these systems highly attractive. Early research investigating the potential of cubic phases as delivery systems showed that several peptides or proteins entrapped within these gel-based systems showed retarded release. Furthermore, entrapment within the cubic phase protected the selected peptide or protein from chemical and physical degradation with its native confirmation and bioactivity retained. AREAS COVERED IN THIS REVIEW: In this review, the literature pertaining to the delivery of various bioactives from cubic liquid crystalline phases is examined, with a particular focus on peptides and proteins. The scope and limitations of the cubic phases in this respect and the future of cubic liquid crystalline systems as sustained delivery systems are highlighted. WHAT THE READER WILL GAIN: The reader will be able to gain an understanding of the properties of the bicontinuous cubic phase and how its structural attributes make these systems desirable for sustained delivery of bioactives, in particular peptides and proteins, but also how these same structural properties have hindered progress towards clinical applications. Current strategies to overcome these issues will also be discussed. TAKE HOME MESSAGE: The bicontinuous cubic phase offers great potential in the field of peptide and protein delivery, but limited research in this area precludes definite conclusions to its future in this respect.
机译：领域的重要性：自组装脂质基液晶系统是一个广泛而活跃的研究领域。在这些中间相中，具有高度扭曲的双层和两个不相交的水通道的立方相已被广泛研究用于药物递送。立方相已被证明可以适应和控制具有不同物理化学性质的药物的释放。而且，用于制备这些递送系统的脂质通常便宜，安全且可生物降解，从而使这些系统极具吸引力。早期研究立方相作为输送系统潜力的研究表明，包裹在这些基于凝胶的系统中的几种肽或蛋白质表现出延迟释放。此外，在立方相中的截留保护了选定的肽或蛋白质免于化学和物理降解，并保留了其天然的确认和生物活性。这篇综述中涉及的领域：在这篇综述中，研究了与从立方液晶相中输送各种生物活性物质有关的文献，特别是针对肽和蛋白质。在这方面，强调了立方相的范围和局限性，以及作为持续输送系统的立方液晶系统的未来。读者将学到什么：读者将能够理解双连续立方相的性质及其结构属性如何使这些系统对于生物活性物质（尤其是肽和蛋白质）的持续输送具有理想的作用，以及这些相同的结构如何特性阻碍了临床应用的进展。还将讨论解决这些问题的当前策略。寄语：双连续立方相在肽和蛋白质输送领域具有巨大潜力，但是在这一领域的有限研究排除了在这方面对其未来的明确结论。

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