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MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases.

机译:血浆和血清中的MicroRNA鉴定:诊断和监测疾病的新工具。

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摘要

MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression at the posttranscriptional level by degrading or blocking translation of messenger RNA (mRNA) targets. MiRNAs play important regulatory roles in a variety of cellular functions as well as in several diseases, including cancer. MiRNA-specific expression profiles have been reported for several pathological conditions. Recently, the discovery of miRNAs in serum opens up the possibility of using miRNAs as biomarkers of disease. In this review, we discuss the potential use of miRNAs as clinically diagnostic biomarkers of various cancers and other diseases as well as the approaches used to detect these molecules in serum and plasma.
机译:MicroRNA(miRNA)是一类小的非编码RNA,通过降解或阻断信使RNA(mRNA)靶标的翻译来调节转录后水平的基因表达。 MiRNA在多种细胞功能以及包括癌症在内的多种疾病中起着重要的调节作用。已经报道了几种病理状况的miRNA特异性表达谱。最近,在血清中发现miRNA开启了将miRNA用作疾病生物标志物的可能性。在这篇综述中,我们讨论了miRNA作为各种癌症和其他疾病的临床诊断生物标志物的潜在用途,以及用于检测血清和血浆中这些分子的方法。

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