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首页> 外文期刊>Expert opinion on biological therapy >Chimeric antigen receptor (CAR)-engineered lymphocytes for cancer therapy.
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Chimeric antigen receptor (CAR)-engineered lymphocytes for cancer therapy.

机译：嵌合抗原受体（CAR）工程化的淋巴细胞，用于癌症治疗。

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INTRODUCTION: Chimeric antigen receptors (CARs) usually combine the antigen binding site of a monoclonal antibody with the signal activating machinery of a T cell, freeing antigen recognition from MHC restriction and thus breaking one of the barriers to more widespread application of cellular therapy. Similar to treatment strategies employing monoclonal antibodies, T cells expressing CARs are highly targeted, but additionally offer the potential benefits of active trafficking to tumor sites, in vivo expansion and long-term persistence. Furthermore, gene transfer allows the introduction of countermeasures to tumor immune evasion and of safety mechanisms. AREAS COVERED: The basic structure of so-called first and later generation CARs and their potential advantages over other immune therapy systems. How these molecules can be grafted into immune cells (including retroviral and non-retroviral transduction methods) and strategies to improve the in vivo persistence and function of immune cells expressing CARs. Examples of tumor-associated antigens that have been targeted in preclinical models and clinical experience with these modified cells. Safety issues surrounding CAR gene transfer into T cells and potential solutions to them. EXPERT OPINION: Because of recent advances in immunology, genetics and cell processing, CAR-modified T cells will likely play an increasing role in the cellular therapy of cancer, chronic infections and autoimmune disorders.
机译：简介：嵌合抗原受体（CARs）通常将单克隆抗体的抗原结合位点与T细胞的信号激活机制结合在一起，使抗原识别不受MHC限制，从而打破了细胞疗法更广泛应用的障碍之一。与采用单克隆抗体的治疗策略相似，表达CAR的T细胞具有高度靶向性，但还具有主动转运至肿瘤部位，体内扩增和长期持久性的潜在优势。此外，基因转移允许引入针对肿瘤免疫逃逸的对策和安全机制。覆盖的领域：所谓的第一代和第二代CAR的基本结构及其与其他免疫治疗系统相比的潜在优势。如何将这些分子移植到免疫细胞中（包括逆转录病毒和非逆转录病毒转导方法），以及改善表达CAR的免疫细胞的体内持久性和功能的策略。在这些修饰的细胞的临床前模型和临床经验中已靶向的肿瘤相关抗原的例子。围绕CAR基因转移到T细胞中的安全性问题及其潜在解决方案。专家意见：由于免疫学，遗传学和细胞加工方面的最新进展，CAR修饰的T细胞可能在癌症，慢性感染和自身免疫性疾病的细胞治疗中起越来越重要的作用。

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