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首页> 外文期刊>Expert opinion on biological therapy >Stem cell transplantation as a biological therapy for peripheral T-cell lymphomas.
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Stem cell transplantation as a biological therapy for peripheral T-cell lymphomas.

机译：干细胞移植作为外周T细胞淋巴瘤的生物疗法。

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摘要

IMPORTANCE OF THE FIELD: Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of non-Hodgkin's lymphomas in which conventional chemotherapy has been characterized by poor outcomes when compared with most aggressive B-cell lymphomas. Autologous, and to a lesser extent allogeneic, hematopoietic stem-cell transplant (HSCT) have been advocated as potential means to improve and consolidate remissions in PTCL. AREAS COVERED IN THIS REVIEW: Given the absence of large-scale randomized clinical controlled trials of transplantation for PTCL, we review existing data addressing the role and timing of HSCT in PTCL. WHAT THE READER WILL GAIN: A detailed overview of the available data of overall and progression-free survival associated with HSCT in PTCL with discussion of existing studies, data on determinants of HSCT outcome in PTCL, and future directions for research. TAKE HOME MESSAGE: The optimal roles and timing of HSCT in PTCL remain unclear. Accordingly, clinicians are encouraged to register their patients in PTCL registry studies and enroll them in clinical trials investigating the role of HSCT. Risk-adapted treatment strategies utilizing identified prognostic parameters may provide future means for identifying the optimal use of HSCT for patients with PTCL, but additional studies are needed before such approaches can be routinely applied.
机译：领域的重要性：周围性T细胞淋巴瘤（PTCL）是一组非霍奇金淋巴瘤，与大多数侵袭性B细胞淋巴瘤相比，常规化疗的预后较差。自体造血干细胞移植（HSCT）被认为是改善和巩固PTCL缓解的潜在手段，但程度较轻。这篇综述所涉及的领域：鉴于缺乏PTCL移植的大规模随机临床对照试验，我们回顾了现有数据，探讨了HSCT在PTCL中的作用和时机。读者将获得什么：PTCL中与HSCT相关的总体生存和无进展生存的可用数据的详细概述，包括对现有研究的讨论，PTCL中HSCT结果决定因素的数据以及未来的研究方向。寄语：尚不清楚HSCT在PTCL中的最佳角色和时机。因此，鼓励临床医生在PTCL注册表研究中为其患者进行注册，并将他们纳入研究HSCT作用的临床试验中。利用已确定的预后参数进行适应风险的治疗策略可能会为将来确定PTCL患者HSCT的最佳用途提供手段，但是在常规应用此类方法之前还需要进行其他研究。

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