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Current developments in cell- and biomaterial-based approaches for stroke repair

机译：基于细胞和生物材料的中风修复方法的最新进展

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Introduction: Stroke is one of the most devastating diseases and a leading cause of mortality worldwide. So far, clinical management of stroke involves surgical clot retrieval or thrombolytic treatment inducing reperfusion of the occluded vessels in the cerebral infarcted area, which is dependent on early intervention following insult. New treatment strategies involve the promotion of angiogenesis and neuroplasticity, stimulation of endogenous neurogenesis, remyelinization, and immunomodulation by means of cell transplantation and sustained drug delivery.Areas covered: This review describes different types of stem cells (endogenous and exogenous neural progenitors, pluripotent stem cell derivatives, mesenchymal stem cells [MSCs], olfactory ensheathing cells) and biomaterials, their routes of administration, means of noninvasive imaging, and the prerequisites and hurdles for the successful translation of the cell therapies to the clinic.Expert opinion: Neural precursors (NPs) derived from pluripotent stem cells, unlike MSCs, can not only remodel the CNS by promoting neuroplasticity, angiogenesis, and immunomodulation, but also replace damaged cells. To transfer NPs into the clinic, step by step guidelines for researchers are identified and discussed.
机译：简介：中风是全球最具破坏力的疾病之一，也是导致死亡的主要原因。迄今为止，中风的临床管理包括外科手术凝块恢复或溶栓治疗，以诱导脑梗塞区域的闭塞血管再灌注，这取决于损伤后的早期干预。新的治疗策略包括促进血管生成和神经可塑性，通过细胞移植和持续药物输送来刺激内源性神经发生，髓鞘再生和免疫调节。涵盖的领域：本综述描述了不同类型的干细胞（内源性和外源性神经祖细胞，多能干细胞）细胞衍生物，间充质干细胞（MSCs），嗅鞘细胞），生物材料，给药途径，无创成像手段以及将细胞疗法成功应用于临床的先决条件和障碍。专家意见：神经前体（与MSC不同，源自多能干细胞的NPs不仅可以通过促进神经可塑性，血管生成和免疫调节来重塑CNS，还可以替代受损的细胞。要将NP转移到临床，需要确定并讨论研究人员的分步指南。

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