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Novel strategies for Alzheimer's disease treatment.

机译：阿尔茨海默氏病治疗的新策略。

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Considerable progress has been made in recent years towards better understanding the pathogenesis of Alzheimer's disease (AD), a dementing neurodegenerative disorder that affects > 10 million individuals in the US and Europe combined. Recent studies suggest that alterations in the processing of amyloid precursor protein (APP), resulting in the accumulation of amyloid-beta protein (Abeta) and the formation of oligomers leads to synaptic damage and neurodegeneration. Therefore, strategies for treatment development have been focused on reducing Abeta accumulation using, among other approaches, antiaggregation molecules, regulators of the APP proteolysis and processing, reducing APP production (e.g., small-interfering RNA), and increasing Abeta clearance with antibodies, apolipoprotein E and Abeta-degrading enzymes (e.g., neprilysin). The main focus of this review is on novel treatments for AD with a special emphasis on delivering neuroprotective and antiamyloidogenic molecules by gene therapy and by promoting neurogenesis.
机译：近年来，在更好地了解阿尔茨海默氏病（AD）的发病机理方面取得了可观的进展，该病是一种痴呆性神经退行性疾病，在美国和欧洲的总人数超过1000万。最近的研究表明，淀粉样蛋白前体蛋白（APP）的加工过程发生变化，导致淀粉样β蛋白（Abeta）的积累和寡聚体的形成会导致突触损伤和神经变性。因此，治疗开发的策略集中在使用抗聚集分子，APP蛋白水解和加工的调节剂，减少APP的产生（例如，小干扰RNA）以及增加抗体，载脂蛋白对Abeta的清除等方面来减少Abeta的积累。 E和Abeta降解酶（例如neprilysin）。这篇综述的主要重点是针对AD的新疗法，特别强调通过基因疗法和促进神经发生来递送神经保护和抗淀粉样蛋白分子。

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