Prospects for and barriers to a fungal vaccine.

Spellberg B

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Prospects for and barriers to a fungal vaccine.

机译：真菌疫苗的前景和障碍。

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Vaccination is a desirable strategy to prevent life-threatening fungal infections. Candidiasis is the most common invasive fungal infection, and promising vaccine targets are nearing clinical testing to prevent such infections. One barrier to developing antifungal vaccines is the perceived risk of blunted immune responses in at-risk patients. However, vaccines stimulate effective immune responses even in highly immunocompromised patients. The biggest barrier to development of fungal vaccines is the lack of available capital to translate discoveries made at the bench into biologics used at the bedside. Nevertheless, vaccines targeting invasive fungal infections are an extremely promising avenue of research and development. It is desirable that additional sources of capital be made available to academic scientists to facilitate development of such vaccines.

机译：接种疫苗是预防威胁生命的真菌感染的理想策略。念珠菌病是最常见的侵袭性真菌感染，有希望的疫苗靶点正在接近临床测试以预防此类感染。开发抗真菌疫苗的一个障碍是高危患者的免疫反应迟钝的风险。但是，即使在高度免疫功能低下的患者中，疫苗也会刺激有效的免疫反应。真菌疫苗开发的最大障碍是缺乏可用的资金，无法将板凳上的发现转化为床边使用的生物制剂。然而，针对侵袭性真菌感染的疫苗是极为有前途的研发途径。期望提供额外的资金来源给学术科学家以促进这种疫苗的开发。

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《Expert opinion on biological therapy》 |2007年第12期|共4页
作者
Spellberg B;
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正文语种 eng
中图分类治疗学;
关键词
Animals; Candidiasis; Clinical Trials as Topic; Drugs; Investigational; Expert Testimony; 动物; 念珠菌病; 药物; 临床试用; 司法鉴定; 真菌菌苗; 小鼠; 危险因素; 美国;

机译：Animals;Candidiasis;Clinical Trials as Topic;Drugs;Investigational;Expert Testimony;动物;念珠菌病;药物;临床试用;司法鉴定;真菌菌苗;小鼠;危险因素;美国;

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机译：真菌疫苗的前景和障碍。
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6. Correction: Tendler M. et al. Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human(itarian) Vaccine. Trop. Med. Infect. Dis. 2018 3 121 [O] . Miriam Tendler, Marília S. Almeida, Monica M. Vilar, 2019

机译：校正：TendlerM.等。 Sm14 / GLA-SE血吸虫病疫苗的现状：克服针对第一个抗寄生虫性人（意大利）疫苗的障碍和范例。放下中感染。 Dis。 20183121
7. Correction: Tendler, M., et al. Current Status of the Sm14/GLA-SE Schistosomiasis Vaccine: Overcoming Barriers and Paradigms towards the First Anti-Parasitic Human(itarian) Vaccine. Trop. Med. Infect. Dis. 2018, 3, 121 [O] . Miriam Tendler, Marília Almeida, Monica Vilar, 2019

机译：纠正：Tendler，M.等人。 SM14 / GLA-SE Schistosomiaisis疫苗的当前状态：克服障碍和范式朝向第一个抗寄生虫人（IRARIAR）疫苗。倾斜。 Med。感染。解释。 2018,3,121

Prospects for and barriers to a fungal vaccine.

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