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首页> 外文期刊>Expert opinion on biological therapy >DNA vaccine therapy for chronic hepatitis C virus (HCV) infection: immune control of a moving target.
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DNA vaccine therapy for chronic hepatitis C virus (HCV) infection: immune control of a moving target.

机译：用于慢性丙型肝炎病毒（HCV）感染的DNA疫苗疗法：移动目标的免疫控制。

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The use of DNA plasmids for DNA vaccination was first described in the early 1990 s. DNA vaccinations were successful in small animal models but in larger animals and humans problems appeared. One major obstacle, effective delivery, has been partly overcome by new delivery techniques, such as transdermal delivery with the gene gun, and in vivo electroporation. We are entering a new era of DNA vaccination, where such techniques can be tested in humans. DNA vaccination may be a useful therapy for chronic hepatitis C virus (HCV) infections. Patients with these infections have a reduced T cell response to the invading virus. The genetic variability of HCV, its immunomodulatory properties and high replication rate contribute to chronicity. By providing the correct stimulus T cells may be activated to clear the infection. The vaccination is intended to induce a coordinated immune-based attack on the continuously moving HCV target. If effective, this should help in clearing the infection.
机译：在1990年代初首次描述了使用DNA质粒进行DNA疫苗接种。 DNA疫苗在小型动物模型中很成功，但在大型动物和人类中出现了问题。一种主要障碍，即有效递送，已被新的递送技术部分克服，例如基因枪的透皮递送和体内电穿孔。我们正在进入DNA疫苗接种的新时代，这种技术可以在人类中进行测试。 DNA疫苗接种可能是治疗慢性丙型肝炎病毒（HCV）的有用疗法。这些感染的患者对入侵病毒的T细胞反应降低。 HCV的遗传变异性，其免疫调节特性和高复制率有助于慢性病。通过提供正确的刺激，可以激活T细胞以清除感染。接种疫苗旨在对连续移动的HCV目标物诱导基于免疫的协同攻击。如果有效，这将有助于清除感染。

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