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Targeting of eosinophils in asthma.

机译:针对哮喘中的嗜酸性粒细胞。

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Severe asthma continues to be an important source of morbidity despite the availability of bronchodilators and corticosteroids. Although new treatments are needed, better identification of asthma phenotypes may improve treatment effectiveness. One phenotype that has emerged is eosinophilic asthma. Eosinophils in asthma have been studied for many years, and the evidence suggests they play a major role in some forms of asthma. Eosinophilic asthma can be diagnosed using peripheral blood, sputum eosinophil count or exhaled nitric oxide. Depletion of eosinophils can be achieved by corticosteroids, specific anti-interleukin 5 (IL-5) or anti-IL-5-receptor-alpha therapies, or anti-immunoglobulin E approaches. This editorial refers to the approaches that are being taken in eosinophilic asthma with emphasis on the new investigational anti-IL-5-receptor-alpha antibody, benralizumab.
机译:尽管可以使用支气管扩张药和皮质类固醇,但严重的哮喘仍然是发病的重要来源。尽管需要新的治疗方法,但更好地识别哮喘表型可以提高治疗效果。已经出现的一种表型是嗜酸性哮喘。嗜酸性粒细胞在哮喘中的研究已经进行了多年,证据表明它们在某些形式的哮喘中起主要作用。嗜酸性粒细胞性哮喘可通过外周血,痰中嗜酸性粒细胞计数或呼出的一氧化氮进行诊断。糖皮质激素,特异性抗白介素5(IL-5)或抗IL-5-受体-α疗法或抗免疫球蛋白E疗法可实现嗜酸性粒细胞的耗竭。这篇社论指的是在嗜酸性粒细胞性哮喘中采用的方法,重点是新的研究性抗IL-5-受体-α抗体贝那利珠单抗。

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