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首页> 外文期刊>Expert opinion on biological therapy >Nanoparticles disguised as red blood cells to evade the immune system.
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Nanoparticles disguised as red blood cells to evade the immune system.

机译：伪装成红细胞的纳米颗粒可逃避免疫系统。

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The development of nanoparticle platforms with long in vivo circulation half-life has long been one of the major goals in the field of cancer drug delivery. Long-circulating nanoparticles can more effectively localize to the tumor site through either passive or active targeting mechanisms. The current gold standard for bestowing long-circulating attributes involves the use of PEG, which surrounds the particles with a hydration layer and thereby prevents recognition by the mononuclear phagocyte system. Recently, a new strategy for synthesizing biomimetic nanoparticles has been inspired by the body's own long-circulating entities, red blood cells (RBCs). Such a system disguises drug nanocarriers as 'self' using membrane materials directly derived from RBCs. This method has been demonstrated to prolong particle systemic circulation half-life beyond that of the corresponding PEGylated systems. The RBC membrane-coated nanoparticles present a major breakthrough in drug delivery technology and show great promise for clinical applications. Herein we highlight the significance and the unique features of this nature-inspired nanoparticle platform and offer opinions on its future prospects.
机译：具有长的体内循环半衰期的纳米颗粒平台的开发长期以来一直是癌症药物递送领域的主要目标之一。长循环的纳米颗粒可以通过被动或主动靶向机制更有效地定位在肿瘤部位。当前赋予长效循环特性的金标准涉及使用PEG，PEG的水合层包围着颗粒，从而阻止了单核吞噬细胞系统的识别。最近，人体自身长期循环的实体红细胞（RBC）启发了一种合成仿生纳米粒子的新策略。这种系统使用直接来源于RBC的膜材料将药物纳米载体伪装成“自身”。已证明该方法可延长颗粒系统循环半衰期，使其超过相应的PEG化系统。 RBC膜包被的纳米颗粒在药物递送技术方面取得了重大突破，并在临床应用中显示出巨大的希望。在本文中，我们重点介绍了这个灵感来自大自然的纳米粒子平台的重要性和独特功能，并就其未来前景提供了意见。

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