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首页> 外文期刊>Expert opinion on biological therapy >Acceptability of switching adalimumab from a prefilled syringe to an autoinjection pen.
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Acceptability of switching adalimumab from a prefilled syringe to an autoinjection pen.

机译：将阿达木单抗从预装注射器切换为自动注射笔的可接受性。

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OBJECTIVE: To assess patients' acceptance of switching adalimumab from a prefilled syringe to an autoinjection pen. METHODS: A two-phase cross-sectional study. The first phase consisted of a 2-h information/education session to present the pen and assist patients in learning its use. At the end of the session, patients completed a self-administered questionnaire regarding usefulness of the meeting. At the next hospital pharmacy dispensing visit the autoinjection pen was provided. Four single-use prefilled devices (40 mg/0.8 ml every other week) were provided. RESULTS: The study population included 55 patients (rheumatoid arthritis 29, psoriatic arthritis 17, ankylosing spondylitis 9). Attendees showed a high degree of satisfaction with the education session (between 72.7 and 90.9% rated the relevant items of the questionnaire in the highest category). Fifty-one patients participated in the second phase of the study. Patients reported 100% adherence to treatment with the autoinjection pen. The percentage of patients self-administering medication increased from 51 to 84% and the percentage attending primary care for injection decreased from 33 to 2%. Pain at the injection site was significantly reduced with the use of the autoinjection pen. The mean (sd) visual analogue scale (VAS) score was 3.52 (2.26) for the syringe compared with 2.02 (2.16) for the pen (p < 0.001). Forty-four (86.3%) patients considered that the use of the autoinjection pen was easier than the syringe, and 96.1% chose the pen as their preferred delivery system. CONCLUSIONS: This study provides further evidence to support the use of the autoinjection pen as a delivery option for adalimumab therapy.
机译：目的：评估患者是否接受将阿达木单抗从预填充注射器改为自动注射笔。方法：两阶段横截面研究。第一阶段包括2小时的信息/教育会议，以介绍笔并协助患者学习其使用方法。在会议结束时，患者填写了有关会议有用性的自我管理调查表。在下次医院药房配药时，提供了自动注射笔。提供了四个一次性使用的预灌装设备（每隔一周40 mg / 0.8 ml）。结果：研究人群包括55名患者（类风湿关节炎29，银屑病关节炎17，强直性脊柱炎9）。与会者对教育课程表示高度满意（在最高类别中，问卷的相关项目得分为72.7％至90.9％）。 51名患者参加了研究的第二阶段。患者报告了100％坚持使用自动注射笔进行治疗。自我用药的患者百分比从51％增加到84％，而接受初级保健注射的百分比从33％减少到2％。使用自动注射笔可大大减少注射部位的疼痛。注射器的平均（sd）视觉模拟量表（VAS）评分为3.52（2.26），而笔为2.02（2.16）（p <0.001）。四十四（86.3％）名患者认为使用自动注射笔比注射器更容易，而96.1％的患者选择了自动注射笔作为首选的递送系统。结论：本研究提供了进一步的证据来支持使用自动注射笔作为阿达木单抗治疗的递送选择。

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