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首页> 外文期刊>Expert opinion on biological therapy >The role of tocilizumab in the management of rheumatoid arthritis.
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The role of tocilizumab in the management of rheumatoid arthritis.

机译：托珠单抗在类风湿关节炎治疗中的作用。

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INTRODUCTION: The introduction of biological treatments has improved the outlook for patients diagnosed with rheumatoid arthritis. There are now a range of different agents, targeting various pathways involved in the inflammatory process. Tocilizumab , a fully humanised anti-interleukin-6 receptor monoclonal antibody is licensed for the treatment of rheumatoid arthritis and systemic juvenile idiopathic arthritis. AREAS COVERED: This article reviews and appraises the available evidence regarding the efficacy and safety of tocilizumab in rheumatoid arthritis, as identified in PubMed and Embase searches. EXPERT OPINION: Clinical trial data suggest that tocilizumab has similar efficacy both clinically and in reducing structural progression to that seen with the TNF inhibitors. Patients who might be particularly suitable for tocilizumab are those who have failed multiple TNF inhibitors, those with a high inflammatory response as part of their disease and those unable to tolerate methotrexate, given the good responses seen with monotherapy.
机译：简介：生物疗法的引入改善了被诊断为类风湿关节炎的患者的前景。现在有多种不同的药物，针对炎症过程中涉及的各种途径。完全人源化的抗白介素6受体单克隆抗体Tocilizumab被许可用于治疗类风湿性关节炎和全身性幼年特发性关节炎。覆盖的区域：本文对Pubiced和Embase搜索中确定的关于tocilizumab在类风湿关节炎中的功效和安全性的可用证据进行了评估。专家意见：临床试验数据表明，与TNF抑制剂相比，托珠单抗在临床上和在减少结构进展方面具有相似的功效。考虑到单一疗法的良好反应，可能特别适合于tocilizumab的患者是那些多种TNF抑制剂治疗失败的患者，作为其疾病一部分具有较高炎症反应的患者以及不能耐受甲氨蝶呤的患者。

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