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Prospect for kidney bioengineering: shortcomings of the status quo

机译:肾脏生物工程的前景:现状的缺点

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Introduction: Dialysis and renal transplantation are the only two therapeutic options offered to patients affected by end-stage kidney disease; however, neither treatment can be considered definitive. In fact, dialysis is able to replace only the filtration function of the kidney without substituting its endocrine and metabolic roles, and dramatically impacts on patient's quality of life. On the other hand, kidney transplantation is severely limited by the shortage of transplantable organs, the need for immunosuppressive therapies and a narrow half-life. Regenerative medicine approaches are promising tools aiming to improve this condition.
机译:简介:透析和肾脏移植是为终末期肾脏疾病患者提供的仅有的两种治疗选择。但是,这两种治疗都不能被认为是确定的。实际上,透析仅能替代肾脏的过滤功能,而不替代其内分泌和代谢作用,并且对患者的生活质量产生重大影响。另一方面,由于可移植器官的缺乏,对免疫抑制疗法的需求和半衰期狭窄,肾脏移植受到严重限制。再生医学方法是旨在改善这种状况的有前途的工具。

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