Dupilumab for the treatment of atopic dermatitis: A clinical trial review

McGregor Sean; Farhangian Michael E.; Feldman Steven R.

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Dupilumab for the treatment of atopic dermatitis: A clinical trial review

机译：Dupilumab治疗特应性皮炎的临床试验回顾

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Introduction: Current treatment options for moderate-to-severe atopic dermatitis (AD) are limited and have potentially dangerous side effects. Dupilumab is a novel monoclonal antibody that was recently studied in adult patients with moderate-to-severe AD. Dupilumab inhibits interleukin-4 (IL-4) and interleukin-13 (IL-13) signaling and was previously found to be effective in asthma. Considering that both AD and asthma are Th2 cell-mediated inflammatory processes, it is reasonable to suspect that dupilumab would be beneficial in AD.'

机译：简介：当前用于中度至重度特应性皮炎（AD）的治疗方法有限，并且具有潜在的危险副作用。 Dupilumab是一种新型单克隆抗体，最近在患有中度至重度AD的成年患者中进行了研究。 Dupilumab抑制白介素4（IL-4）和白介素13（IL-13）信号传导，先前已发现在哮喘中有效。考虑到AD和哮喘都是Th2细胞介导的炎症过程，因此有理由怀疑dupilumab对AD有益。

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《Expert opinion on biological therapy》 |2015年第11期|共4页
作者
McGregor Sean; Farhangian Michael E.; Feldman Steven R.;
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正文语种 eng
中图分类治疗学;
关键词
eczema; interleukin-13; interleukin-4; itch; pruritus; quality of life; sleep;

机译：湿疹;白细胞介素-13;白细胞介素-4;痒;瘙痒;生活质量;睡眠;

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1. Dupilumab for the treatment of atopic dermatitis: A clinical trial review [J] . McGregor Sean, Farhangian Michael E., Feldman Steven R. Expert opinion on biological therapy . 2015,第11期

机译：Dupilumab治疗特应性皮炎的临床试验回顾
2. Dupilumab with concomitant topical corticosteroid treatment in adults with atopic dermatitis with an inadequate response or intolerance to ciclosporin A or when this treatment is medically inadvisable: a placebo‐controlled, randomized phase III III clinical trial ( LIBERTY AD CAFé LIBERTY AD CAFé ) [J] . Bruin‐Weller M., Tha?i D., Smith C.H., British Journal of Dermatology . 2018,第5期

机译：Dupilumab具有伴随局部皮质类固醇治疗的成人，具有特应性皮炎，对Ciclosporin A或Inthine治疗的不耐受性：在医学上不可行：安慰剂控制的随机期III III临床试验（LibertyAdcaféLibertyAdcafé）
3. Efficacy and Safety of Multiple Dupilumab Dose Regimens After Initial Successful Treatment in Patients With Atopic Dermatitis A Randomized Clinical Trial [J] . Worm Margitta, Simpson Eric L., Thaci Diamant, JAMA dermatology . 2020,第2期

机译：特应性皮炎患者初始成功治疗后多发性杜氏菌菌剂量方案的疗效和安全性
4. A systematic review of randomized controlled trials for prevention or treatment of atopic dermatitis in dogs: 2008-2011 update [C] . Thierry Olivry, Petra Bizikova World Congress of Veterinary Dermatology . 2013

机译：对狗的预防或治疗特应性皮炎的随机对照试验进行系统综述：2008-2011更新
5. Topical Probiotics in the Treatment of Atopic Dermatitis: A Randomized Controlled Trial [D] . Chen, Jessica. 2018

机译：局部益生菌治疗特应性皮炎：随机对照试验
6. Dupilumab Maintains Long-Term Disease Control in Adults with Moderate-to-Severe Atopic Dermatitis as Measured by Well-Controlled Weeks: Results From the LIBERTY AD CHRONOS Clinical Trial [O] . Jashin J. Wu, Lynda Spelman, Jerry L. Tan, 2021

机译：Dupilumab通过良好控制的几周测量的具有中度至严重的特征性皮炎的成年人中的长期疾病控制：来自自由AD Chronos临床试验的结果
7. Dupilumab treatment improves quality of life in adult patients with moderate-to-severe atopic dermatitis: results from a randomized, placebo-controlled clinical trial [O] . A. Tsianakas, T.A. Luger, A. Radin 2018

机译：Dupilumab治疗改善了成年患者的生活质量，中度至严重的特征性皮炎：来自随机，安慰剂对照的临床试验的结果

Dupilumab for the treatment of atopic dermatitis: A clinical trial review

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