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首页> 外文期刊>Expert opinion on biological therapy >Endogenous morphine: opening new doors for the treatment of pain and addiction.
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Endogenous morphine: opening new doors for the treatment of pain and addiction.

机译：内源性吗啡：为治疗疼痛和成瘾打开了新的大门。

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Nitric oxide (NO) signalling is at the forefront of intense research interest because its many effects remain controversial and seemingly contradictory. This paper examines its role as a potential mediator of pain and tolerance. Within this context discussion covers endogenous morphine, documenting its ability to be made in animal tissues, including nervous tissue, and in diverse animal phyla. Supporting morphine as an endogenous signalling molecule is the presence of the newly cloned mu3 opiate receptor subtype found in animal (including human) immune, vascular and neural tissues, which is coupled to NO release. Importantly, this mu opiate receptor subtype is morphine-selective and opioid peptide-insensitive, further highlighting the presence of morphinergic signalling coupled to NO release. These findings provide novel insights into pain and tolerance as morphinergic signalling exhibits many similarities with NO actions. Taken together, a select morphinergic signalling system utilising NO opens the gate for the development of novel pharmaceuticals and/or the use of old pharmaceuticals in new ways.
机译：一氧化氮（NO）信号一直是引起广泛研究兴趣的最前沿，因为它的许多作用仍然是有争议的，而且似乎矛盾。本文考察了其作为疼痛和耐受性的潜在介导者的作用。在这种情况下，讨论涵盖了内源性吗啡，记录了其在动物组织（包括神经组织）和各种动物门中制成的能力。支持吗啡作为内源性信号分子的是在动物（包括人类）免疫，血管和神经组织中发现的新克隆的mu3阿片受体亚型的存在，这与NO的释放有关。重要的是，这种阿片受体亚型对吗啡选择性且对阿片样肽不敏感，这进一步突出了与NO释放偶联的吗啡能信号传导的存在。这些发现提供了对疼痛和耐受性的新颖见解，因为吗啡能信号传导表现出许多与NO作用相似的特征。综上所述，利用NO的选择性吗啡能信号传导系统为开发新药物和/或以新方式使用旧药物打开了大门。

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