• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Expert opinion on biological therapy >Immune classification of colorectal cancer patients: impressive but how complete?
【24h】

Immune classification of colorectal cancer patients: impressive but how complete?

机译：大肠癌患者的免疫分类：令人印象深刻，但如何完成？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

There is now accumulating evidence to suggest that intratumoral adaptive immune responses predict patient prognosis. The presence of tumor-infiltrating lymphocytes has been correlated with patients' disease-free and overall survival. Recent exciting studies of human colorectal cancers (CRCs) have underlined the significance of including immunological biomarkers as prognostic markers. AREAS COVERED: This review covers recent literature which suggests that the type, density and location of immune cells within the colorectal tumors represent a better predictor of patient survival than the histopathological methods currently used to stage CRC. EXPERT OPINION: Remarkably, the quantity, quality and spatial distribution of immune cells within the tumor has a greater prognostic value than the standard tumor staging based on tumor burden, infiltration of draining and regional lymph nodes by tumor cells, and evidence of metastases. In addition, such an immune classification may also have a predictive value. Thus, by increasing the knowledge of the immune events inside the tumors and by better understanding the immune architecture of these tumors as well as the functional programs of their constituents, there will certainly be a more complete idea of how tumors evade from immunosurveillance. This knowledge will help to identify new targets for the development of therapeutic strategies.
机译：现在有越来越多的证据表明肿瘤内适应性免疫反应可以预测患者的预后。肿瘤浸润淋巴细胞的存在与患者的无病生存期和总体生存率相关。最近关于人类大肠癌（CRC）的激动人心的研究强调了将免疫生物标记物作为预后标记物的重要性。覆盖的领域：这篇综述涵盖了近期的文献，这些文献表明，与目前用于分期CRC的组织病理学方法相比，结直肠肿瘤内免疫细胞的类型，密度和位置可以更好地预测患者的生存。专家意见：值得注意的是，肿瘤内免疫细胞的数量，质量和空间分布比基于肿瘤负荷，肿瘤细胞对引流和区域淋巴结浸润以及转移证据的标准肿瘤分期具有更高的预后价值。另外，这种免疫分类也可以具有预测价值。因此，通过增加对肿瘤内部免疫事件的了解，并更好地了解这些肿瘤的免疫结构以及其组成部分的功能程序，无疑将对肿瘤如何逃避免疫监视有了更完整的认识。这些知识将有助于确定治疗策略发展的新目标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号