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首页> 外文期刊>Expert opinion on biological therapy >Protective cancer immunotherapy: what can the innate immune system contribute?
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Protective cancer immunotherapy: what can the innate immune system contribute?

机译：保护性癌症免疫疗法：先天性免疫系统能起什么作用？

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Despite significant efforts to induce protection against malignant diseases, the clinical effects of antitumour vaccines are poor. However, recent studies on a quadrivalent human papilloma virus vaccine suggest that protection against secondary tumour development is feasible. While this scenario benefits rather from antiviral protection than from direct antitumour responses, immunisation against cancers of non-viral origin demands strategies that rely on the circumvention of intrinsic regulatory mechanisms. Strong activation of innate immune cells seems to be key and, thus, the choice of adjuvant determines vaccination efficacy. The recently acquired knowledge about molecular and cellular recognition of microbial molecules suggests how one can modulate innate and adaptive immune reactions to potentially induce robust T- and B-cell reactions capable of prohibiting tumour development and progression. Here, the authors review the present knowledge of innate immune reactions, which may help to define rationales on the design of novel antitumour vaccines.
机译：尽管做出了很大的努力来诱导针对恶性疾病的保护，但是抗肿瘤疫苗的临床效果仍然很差。然而，最近对四价人乳头瘤病毒疫苗的研究表明，针对继发性肿瘤发展的保护是可行的。尽管这种情况受益于抗病毒保护而不是直接抗肿瘤反应，但针对非病毒源性癌症的免疫接种需要采取依赖于内在调节机制的策略。先天免疫细胞的强活化似乎是关键，因此，佐剂的选择决定了疫苗接种的效力。最近获得的有关微生物分子的分子和细胞识别的知识表明，人们如何调节先天性和适应性免疫反应，从而潜在地诱导强大的T细胞和B细胞反应，从而能够阻止肿瘤的发生和发展。在这里，作者回顾了先天免疫反应的当前知识，这可能有助于定义新型抗肿瘤疫苗设计的原理。

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