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首页> 外文期刊>Expert opinion on biological therapy >Additive value of adult bone-marrow-derived cell transplantation to conventional revascularization in chronic ischemic heart disease: a systemic review and meta-analysis.
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Additive value of adult bone-marrow-derived cell transplantation to conventional revascularization in chronic ischemic heart disease: a systemic review and meta-analysis.

机译：成人骨髓来源的细胞移植对慢性缺血性心脏病常规血运重建的附加价值：系统评价和荟萃分析。

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摘要

OBJECTIVE: Whether adult bone marrow (BM)-derived cells (BMCs) transplantation benefits patients with chronic ischemic heart disease (IHD) remains controversial. This systemic and meta-analysis study aimed to assess the potential therapeutic effects of BMCs transplantation with revascularization in chronic IHD. RESEARCH DESIGN AND METHODS: Randomized controlled trials of BMCs in combination with coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) for chronic IHD were identified by searching Medline, Embase, the Cochrane Controlled Trials Register, the Cochrane Library, and the Web of Science. We conducted a random-effects meta-analysis across eligible studies measuring the same outcomes. RESULTS: Ten randomized controlled trials including 422 participants were reviewed. In the trials with six months of follow-up, BMCs transplantation improved left ventricular (LV) ejection fraction (LVEF) by 4.02% and reduced LV end-systolic and end-diastolic volumes. Subgroup analysis revealed a statistically significant difference in LVEF associated with primary intervention, route of cell delivery, cell type, and baseline LVEF, but not with cell dose or storage duration. CONCLUSIONS: Selected-BMCs transplantation through myocardial injection after surgical revascularization may benefit patients with chronic IHD and severely impaired LV function. Due to the limitation of patient number, RCT with larger sample size and long follow-up are required for future research.
机译：目的：成年骨髓（BM）来源的细胞（BMC）移植是否有益于慢性缺血性心脏病（IHD）患者。这项系统和荟萃分析研究旨在评估BMCs移植与慢性IHD血运重建的潜在治疗作用。研究设计和方法：通过搜索Medline，Embase，Cochrane对照试验注册簿，Cochrane库和科学网。我们对符合相同结果的合格研究进行了随机效应荟萃分析。结果：十项随机对照试验，包括422名参与者进行了审查。在为期六个月的随访试验中，BMC移植使左心室射血分数（LVEF）提高了4.02％，并降低了左室收缩末期和舒张末期容积。亚组分析显示，LVEF与主要干预措施，细胞递送途径，细胞类型和基线LVEF相关，但在统计学上无显着差异，但与细胞剂量或储存时间无关。结论：在外科血运重建后通过心肌注射选择的BMCs移植可能有益于慢性IHD和严重LV功能受损的患者。由于患者人数的限制，需要进行更大样本量且需要长期随访的RCT，以进行进一步的研究。

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