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Optimizing the expediency of TNFi in rheumatoid arthritis: offering a TNFi holiday in patients having reached low-disease activity in the maintenance phase

机译:优化TNFi在类风湿性关节炎中的权宜之计:为维持期达到低疾病活性的患者提供TNFi假期

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摘要

Introduction: The treatment of rheumatoid arthritis (RA) has been revolutionized since the introduction of biological disease-modifying antirheumatic drugs such as tumour necrosis factor alpha inhibitors (TNFi), and clinical remission has become a realistic target in the treatment strategy. Discontinuation strategies of TNFi therapy after reaching sustained remission or low-disease activity (LDA) have been emerging. These strategies are important considering the risk-benefit profile of TNFi, as well as looking at them from a cost-economic point of view.
机译:简介:自从引入可改变生物疾病的抗风湿药(例如肿瘤坏死因子α抑制剂(TNFi))以来,类风湿性关节炎(RA)的治疗方法已发生了革命性的变化,临床缓解已成为治疗策略中的现实目标。在达到持续缓解或低疾病活性(LDA)后,TNFi治疗的中止策略已经出现。考虑到TNFi的风险收益特征以及从成本经济的角度来看这些策略,这些策略非常重要。

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