• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Expert opinion on biological therapy >Jaa-f11: extending the life of mice with breast cancer.
【24h】

Jaa-f11: extending the life of mice with breast cancer.

机译：Jaa-f11：延长患有乳腺癌的小鼠的寿命。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

JAA-F11 antibody (Ab) is a monoclonal Ab that is specific for the Thomsen-Friedenreich antigen, Galbeta1-3GalNAcalpha (TF-Ag). TF-Ag, discovered in the late 1920s, is a tumor-associated carbohydrate Ag of many clinically widespread carcinomas. In a mouse model, JAA-F11 Ab significantly extended median survival time of animals with metastatic 4T1 breast tumors and caused > 50% inhibition of lung metastasis. (124)Iodine labeled JAA-F11 Ab in in vivo micro positron emission tomography showed tumor specificity in a mouse breast tumor model, with no preferential uptake by any other organ. Human cancer cell adhesion to vascular endothelium was also blocked by JAA-F11. Structural specificity of the Ab was shown with glycan array analysis and indicated that this Ab, unlike many other Abs to TF-Ag, will not bind to a related glycolipid on natural killer cells, kidney or spleen. Patients with higher levels of naturally occurring anti-TF-Ag Ab appear to have a better prognosis, indicating that passive transfer ofJAA-F11 or active immunization, resulting in production of anti-TF-Ag Ab, would clinically be beneficial for the patient.
机译：JAA-F11抗体（Ab）是特异于Thomsen-Friedenreich抗原Galbeta1-3GalNAcalpha（TF-Ag）的单克隆抗体。 TF-Ag是在1920年代后期发现的，是许多临床广泛癌症中与肿瘤相关的碳水化合物Ag。在小鼠模型中，JAA-F11 Ab显着延长了患有转移性4T1乳腺肿瘤的动物的中位生存时间，并导致了50％以上的肺转移抑制。 （124）碘在体内微正电子发射断层扫描中标记为JAA-F11 Ab，在小鼠乳腺肿瘤模型中显示出肿瘤特异性，任何其他器官均无优先摄取。 JAA-F11也阻断了人类癌细胞对血管内皮的粘附。通过聚糖阵列分析显示了抗体的结构特异性，表明该抗体与许多其他的TF-Ag抗体不同，不会与自然杀伤细胞，肾脏或脾脏上的相关糖脂结合。天然存在的抗TF-Ag Ab含量较高的患者预后较好，这表明JAA-F11的被动转移或主动免疫会产生抗TF-Ag Ab，从临床上对患者有利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号