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首页> 外文期刊>Genetica >Molecular evolution and sequence divergence of plant chalcone synthase and chalcone synthase-Like genes
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Molecular evolution and sequence divergence of plant chalcone synthase and chalcone synthase-Like genes

机译：植物查尔酮合酶和查尔酮合酶样基因的分子进化和序列差异

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Plant chalcone synthase (CHS) and CHS-Like (CHSL) proteins are polyketide synthases. In this study, we evaluated the molecular evolution of this gene family using representative types of CHSL genes, including stilbene synthase (STS), 2-pyrone synthase (2-PS), bibenzyl synthase (BBS), acridone synthase (ACS), biphenyl synthase (BIS), benzalacetone synthase, coumaroyl triacetic acid synthase (CTAS), and benzophenone synthase (BPS), along with their CHS homologs from the same species of both angiosperms and gymnosperms. A cDNA-based phylogeny indicated that CHSLs had diverse evolutionary patterns. STS, ACS, and 2-PS clustered with CHSs from the same species (late diverged pattern), while CTAS, BBS, BPS, and BIS were distant from their CHS homologs (early diverged pattern). The amino-acid phylogeny suggested that CHS and CHSL proteins formed clades according to enzyme function. The CHSs and CHSLs from Polygonaceae and Arachis had unique evolutionary histories. Synonymous mutation rates were lower in late diverged CHSLs than in early diverged ones, indicating that gene duplications occurred more recently in late diverged CHSLs than in early diverged ones. Relative rate tests proved that late diverged CHSLs had unequal rates to CHSs from the same species when using fatty acid synthase, which evolved from the common ancestor with the CHS superfamily, as the outgroup, while the early diverged lineages had equal rates. This indicated that late diverged CHSLs experienced more frequent mutation than early diverged CHSLs after gene duplication, allowing obtaining new functions in relatively short period of time.
机译：植物查耳酮合酶（CHS）和类似CHS的蛋白（CHSL）是聚酮化合物合酶。在这项研究中，我们使用代表性的CHSL基因类型，包括二苯乙烯合酶（STS），2-吡喃酮合酶（2-PS），联苄基合酶（BBS），a啶酮合酶（ACS），联苯，评估了该基因家族的分子进化合酶（BIS），苯并丙酮合酶，香豆酰三乙酸合酶（CTAS）和二苯甲酮合酶（BPS）以及它们被子植物和裸子植物的CHS同源物。基于cDNA的系统发育表明，CHSL具有多种进化模式。 STS，ACS和2-PS与相同物种的CHS聚在一起（后期发散型），而CTAS，BBS，BPS和BIS与它们的CHS同源物相距较远（早期发散型）。氨基酸系统发育研究表明，CHS和CHSL蛋白根据酶的功能形成进化枝。 Poly科和花生科的CHS和CHSL具有独特的进化历史。晚期分化的CHSLs的同义突变率低于早期分化的CHSLs，表明在晚期分化的CHSLs中基因重复发生得比早期分化的CHSLs多。相对速率测试证明，当使用脂肪酸合酶时，晚分离的CHSL与相同物种的CHS具有不相等的速率，脂肪酸合酶是从CHS超家族的共同祖先进化而来的，而早期分离的谱系具有相同的速率。这表明基因复制后，晚期分化的CHSL比早期分化的CHSL经历更频繁的突变，从而允许在相对较短的时间内获得新功能。

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