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首页> 外文期刊>Genes to cells : >Up-regulation of HP1 gamma expression during neuronal maturation promotes axonal and dendritic development in mouse embryonic neocortex
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Up-regulation of HP1 gamma expression during neuronal maturation promotes axonal and dendritic development in mouse embryonic neocortex

机译：在神经元成熟过程中HP1γ表达的上调促进小鼠胚胎新皮层的轴突和树突状发育。

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Immature neurons undergo morphological and physiological changes including axonal and dendritic development to establish neuronal networks. As the transcriptional status changes at a large number of genes during neuronal maturation, global changes in chromatin modifiers may take place in this process. We now show that the amount of heterochromatin protein 1 (HP1) increases during neuronal maturation in the mouse neocortex. Knockdown of HP1 suppressed axonal and dendritic development in mouse embryonic neocortical neurons in culture, and either knockdown or knockout of HP1 impaired the projection of callosal axons of superficial layer neurons to the contralateral hemisphere in the developing neocortex. Conversely, forced expression of HP1 facilitated axonal and dendritic development, suggesting that the increase of HP1 is a rate limiting step in neuronal maturation. These results together show an important role for HP1 in promoting axonal and dendritic development in maturing neurons.
机译：未成熟的神经元会经历形态和生理变化，包括轴突和树突发展，以建立神经元网络。由于神经元成熟过程中大量基因的转录状态发生变化，因此染色质修饰剂的整体变化可能会在此过程中发生。现在，我们显示在小鼠新皮层神经元成熟期间异染色质蛋白1（HP1）的数量增加。敲低HP1会抑制培养的小鼠胚胎新皮层神经元的轴突和树突状发育，敲低或敲除HP1会损害表层神经元call突轴突向发育中的新皮层对侧半球的投射。相反，HP1的强制表达促进了轴突和树突的发展，这表明HP1的增加是神经元成熟的限速步骤。这些结果共同显示了HP1在促进成熟神经元中促进轴突和树突发育中的重要作用。

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