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Efficacy of Heroin-Assisted Treatment in Belgium: A Randomised Controlled Trial

机译：比利时海洛因辅助治疗的有效性：随机对照试验

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Background/Aims: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts still using street heroin after a methadone treatment. In Belgium, a new trial compared the efficacy of a HAT to existing methadone maintenance treatment. Methods: In this randomised controlled trial, HAT was limited to 12 months. Participants were assessed every 3 months. They were responders if they showed improvement on the level of street heroin use, health or criminal involvement. Results: 74 participants were randomised in the trial. The experimental group (n = 36) counted 30% of responders more than the control group (n = 38) at each assessment point (p < 0.05), except at 12 months where the difference (11%) was no longer significant (p = 0.35). Still, after 12 months, participants in the experimental group reported significantly greater improvements (p < 0.05) than the control group on the level of street heroin use and on the level of physical and mental health. Both groups reported significantly less criminal acts after 12 months (p < 0.001), but with no significant difference between the groups. Conclusions: This trial confirms the short-term efficacy of HAT for severe heroin addicts, who already failed methadone treatment. (C) 2015 S. Karger AG, Basel
机译：背景/目的：海洛因辅助治疗（HAT）可以改善美沙酮治疗后仍在使用街头海洛因的海洛因成瘾者的状况。在比利时，一项新的试验将HAT的功效与现有的美沙酮维持治疗进行了比较。方法：在该随机对照试验中，HAT限制为12个月。每3个月对参与者进行一次评估。如果他们对街头海洛因的使用，健康或犯罪参与程度有所改善，他们就是回应者。结果：74名参与者在试验中被随机分配。实验组（n = 36）在每个评估点（p <0.05）的反应者比对照组（n = 38）多30％（p = 0.05），但在12个月时差异（11％）不再显着（p = 0.35）。尽管如此，在12个月后，实验组的参与者在街头海洛因的使用水平和身心健康水平上均比对照组有显着改善（p <0.05）。两组报告的12个月后犯罪行为明显减少（p <0.001），但两组之间无显着差异。结论：该试验证实了HAT对严重美沙酮治疗失败的严重海洛因依赖者的短期疗效。 （C）2015 S.Karger AG，巴塞尔

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