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首页> 外文期刊>European addiction research >Has Previous Abuse of Flunitrazepam Been Replaced by Clonazepam?
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Has Previous Abuse of Flunitrazepam Been Replaced by Clonazepam?

机译:以前的氟硝西epa滥用已被氯硝西Replace所取代吗?

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Background and Aims: For many years, flunitrazepam was the benzodiazepine of choice among users of illegal drugs. The aim of this study was to investigate to which extent clonazepam use has increased in this population, and whether this was related to increased prescription or because of illegal availability. Methods: We used data from three sources to study the changes in the use of clonazepam: (1) Presence and concentrations of clonazepam and flunitrazepam in blood samples collected from Norwegian drugged drivers; (2) Sales numbers (legal market) for clonazepam, extracted from the Norwegian prescription database (NorPD), and (3) Specific seizures (illegal market) for clonazepam in Norway. Results: In 2004, 13.0% of the analysed blood samples from drugged drivers contained clonazepam, whereas this proportion had increased to 27.7% in 2013. In the same period, the frequency of flunitrazepam in drugged drivers decreased from 16.6% in 2004 to 3.2% in 2013. The number of clonazepam prescriptions decreased, while the number of seized tablets containing clonazepam increased considerably from 2004 to 2013. Conclusions: For the last 10 years, a significant increase in the illegal use of clonazepam has been seen, now replacing flunitrazepam as the most used illegal benzodiazepine in Norway. (C) 2015 S. Karger AG, Basel
机译:背景和目标:多年来,氟尼西epa是非法药物使用者中首选的苯二氮卓类药物。这项研究的目的是调查氯硝西am在该人群中的使用增加到何种程度,以及这是否与处方增加有关或是否由于非法获取。方法:我们使用来自三个来源的数据来研究氯硝西am使用的变化:(1)挪威吸毒者血液样本中氯硝西am和氟硝西epa的存在和浓度; (2)从挪威处方数据库(NorPD)中提取的氯硝西Sales的销售数字(合法市场),以及(3)挪威的氯硝西am的特定缉获量(非法市场)。结果:2004年,从吸毒成瘾者中分析出的血液样本中有13.0%含有氯硝西am,而这一比例在2013年增加到27.7%。同期,在吸毒成瘾者中氟硝西epa的发生频率从2004年的16.6%下降到3.2% 2013年,氯硝西am处方数量减少,而从2004年到2013年,缉获的含有氯硝西am的片剂数量大幅增加。结论:在过去10年中,非法使用氯硝西am的人数显着增加,现在已取代氟硝西epa挪威最常用的非法苯二氮卓。 (C)2015 S.Karger AG,巴塞尔

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