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首页> 外文期刊>Genes to cells : >E-cadherin prolongs the moment for interaction between intestinal stem cell and its progenitor cell to ensure Notch signaling in adult Drosophila midgut
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E-cadherin prolongs the moment for interaction between intestinal stem cell and its progenitor cell to ensure Notch signaling in adult Drosophila midgut

机译：E-钙粘着蛋白延长了肠道干细胞与其祖细胞之间相互作用的时间，以确保成人果蝇中肠的Notch信号传导

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摘要

Intestinal stem cells (ISCs) are required for maintenance of the proper cell composition in the adult intestine. To ensure permanent recruitment of newly differentiated cells, the ISC undergoes asymmetric cell division that generates an ISC itself and a progenitor cell. In the Drosophila midgut, cell fate for the absorptive cell is determined by Notch (N) signal in the progenitor cells that receive a ligand Delta (Dl) produced by the ISCs. Although most of the ISCs and progenitor cells are distantly located, they should retain their attachment when N is activated because the Dl-N interaction requires cell adhesion. Furthermore, N cannot be activated before completion of cell division. Thus, the moment after cell division and before cell separation should be prolonged for certain N activation, although the mechanism for this remains unclear. Here, we demonstrate that E-cadherin (E-cad) is required for stable attachment between the two cells. When E-cad does not function, N is not activated and cell differentiation is attenuated. We also show that the ISC tumor by N inactivation is assisted by a defect in E-cad down-regulation. These findings reveal one of the normal N functions used to inhibit tumorigenesis through lowering of E-cad for proper midgut cell turnover.
机译：肠道干细胞（ISC）是维持成人肠道中适当细胞组成所必需的。为确保新分化细胞的永久募集，ISC经历了不对称细胞分裂，产生了ISC本身和祖细胞。在果蝇中肠中，吸收性细胞的细胞命运取决于接受ISC产生的配体Delta（D1）的祖细胞中的Notch（N）信号。尽管大多数ISC和祖细胞位于遥远的地方，但当N被激活时它们应保持其附着，因为D1-N相互作用需要细胞粘附。此外，在细胞分裂完成之前不能激活N。因此，细胞分裂后和细胞分离前的时间应延长某些N的活化，尽管其机制尚不清楚。在这里，我们证明了E-cadherin（E-cad）是两个单元格之间稳定附着所必需的。当E-cad不起作用时，N未被激活，细胞分化减弱。我们还显示，N失活引起的ISC肿瘤是由E-cad下调的缺陷所辅助。这些发现揭示了正常的N功能之一，该正常的N功能是通过降低E-cad使中肠细胞更替而抑制肿瘤发生的。

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